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    Cd4 CD4 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12504, updated on 7-May-2019

    Summary

    Official Symbol
    Cd4provided by MGI
    Official Full Name
    CD4 antigenprovided by MGI
    Primary source
    MGI:MGI:88335
    See related
    Ensembl:ENSMUSG00000023274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L3T4; Ly-4
    Expression
    Biased expression in thymus adult (RPKM 167.0), spleen adult (RPKM 15.0) and 1 other tissue See more
    Orthologs

    Genomic context

    See Cd4 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (124864693..124888248, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124814711..124838227, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32404 Neighboring gene predicted gene, 46975 Neighboring gene G protein-coupled receptor 162 Neighboring gene lymphocyte-activation gene 3 Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene parathymosin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MHC class II protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    immunoglobulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-16 binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-16 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    T cell selection ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    helper T cell enhancement of adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    induction by virus of host cell-cell fusion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-15-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-15-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    maintenance of protein location in cell ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    T-cell differentiation antigen L3T4
    T-cell surface antigen T4/Leu-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013488.3NP_038516.1  T-cell surface glycoprotein CD4 precursor

      See identical proteins and their annotated locations for NP_038516.1

      Status: VALIDATED

      Source sequence(s)
      AK153707, AK161775, BX639790
      Consensus CDS
      CCDS20535.1
      UniProtKB/Swiss-Prot
      P06332
      UniProtKB/TrEMBL
      Q3TSV7
      Related
      ENSMUSP00000024044.6, ENSMUST00000024044.6
      Conserved Domains (5) summary
      smart00410
      Location:131205
      IG_like; Immunoglobulin like
      pfam05790
      Location:128207
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:212316
      CD4-extracel; CD4, extracellular
      pfam12104
      Location:425452
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      cl11960
      Location:29124
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      124864693..124888248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505462.2XP_006505525.1  T-cell surface glycoprotein CD4 isoform X2

      Conserved Domains (4) summary
      smart00410
      Location:131205
      IG_like; Immunoglobulin like
      pfam05790
      Location:128207
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:212316
      CD4-extracel; CD4, extracellular
      cl11960
      Location:29124
      Ig; Immunoglobulin domain
    2. XM_006505461.3XP_006505524.1  T-cell surface glycoprotein CD4 isoform X1

      Conserved Domains (4) summary
      smart00410
      Location:131205
      IG_like; Immunoglobulin like
      pfam05790
      Location:128207
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:212316
      CD4-extracel; CD4, extracellular
      cl11960
      Location:29124
      Ig; Immunoglobulin domain
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