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    Bdh1 3-hydroxybutyrate dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117099, updated on 18-Apr-2019

    Summary

    Official Symbol
    Bdh1provided by RGD
    Official Full Name
    3-hydroxybutyrate dehydrogenase 1provided by RGD
    Primary source
    RGD:620131
    See related
    Ensembl:ENSRNOG00000001736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bdh
    Summary
    mitochondrial membrane enzyme that is dependent on phosphatidylcholine for optimal function [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 732.0), Heart (RPKM 140.3) and 5 other tissues See more
    Orthologs

    Genomic context

    See Bdh1 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72577547..72619435, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (75651886..75693764, complement)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550974 Neighboring gene uncharacterized LOC102550747 Neighboring gene apolipoprotein D Neighboring gene choline-phosphate cytidylyltransferase A-like Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC94818

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    3-hydroxybutyrate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3-hydroxybutyrate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxybutyrate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    3-hydroxybutyrate dehydrogenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adipose tissue development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to growth hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    matrix side of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    D-beta-hydroxybutyrate dehydrogenase, mitochondrial
    Names
    3-hydroxybutyrate dehydrogenase (heart, mitochondrial)
    3-hydroxybutyrate dehydrogenase, type 1
    NP_446447.2
    XP_006248540.1
    XP_008766913.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053995.3NP_446447.2  D-beta-hydroxybutyrate dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_446447.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085916
      UniProtKB/Swiss-Prot
      P29147
      UniProtKB/TrEMBL
      A0A0G2JSH2
      Related
      ENSRNOP00000002366.3, ENSRNOT00000002366.5
      Conserved Domains (2) summary
      cd09805
      Location:57342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:57242
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      72577547..72619435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248478.3XP_006248540.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006248540.1

      UniProtKB/Swiss-Prot
      P29147
      UniProtKB/TrEMBL
      A0A0G2JSH2
      Conserved Domains (2) summary
      cd09805
      Location:57342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:57242
      adh_short; short chain dehydrogenase
    2. XM_008768691.2XP_008766913.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008766913.1

      UniProtKB/Swiss-Prot
      P29147
      UniProtKB/TrEMBL
      A0A0G2JSH2
      Conserved Domains (2) summary
      cd09805
      Location:57342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:57242
      adh_short; short chain dehydrogenase

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      68723790..68758851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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