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    Map3k1 mitogen-activated protein kinase kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116667, updated on 18-Apr-2019

    Summary

    Official Symbol
    Map3k1provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 1provided by RGD
    Primary source
    RGD:620966
    See related
    Ensembl:ENSRNOG00000013177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mekk1
    Summary
    kinase that has E3 ubiquitin ligase to mediate ubiquitination and degradation of ERK1/2 [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Spleen (RPKM 167.6), Kidney (RPKM 149.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Map3k1 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (43329516..43393203, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (62373717..62440715, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene MIER family member 3 Neighboring gene SET domain containing 9 pseudogene Neighboring gene uncharacterized LOC102553935 Neighboring gene uncharacterized LOC102554057

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    JUN kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    JUN kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sphingolipid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of JNKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    eyelid development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    morphogenesis of an epithelial sheet ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    wound healing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filamentous actin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 1
    Names
    MAPK/ERK kinase kinase 1
    MEK kinase 1
    MEKK 1
    mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
    NP_446339.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053887.1NP_446339.1  mitogen-activated protein kinase kinase kinase 1

      See identical proteins and their annotated locations for NP_446339.1

      Status: PROVISIONAL

      Source sequence(s)
      U48596
      UniProtKB/Swiss-Prot
      Q62925
      Related
      ENSRNOP00000017968.3, ENSRNOT00000017968.3
      Conserved Domains (2) summary
      smart00220
      Location:12241489
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06630
      Location:12231490
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      43329516..43393203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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