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    Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 11517, updated on 31-Jan-2019

    Summary

    Official Symbol
    Adcyap1r1provided by MGI
    Official Full Name
    adenylate cyclase activating polypeptide 1 receptor 1provided by MGI
    Primary source
    MGI:MGI:108449
    See related
    Ensembl:ENSMUSG00000029778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAC1; PAC1R; AI846590; PACAP1-R; 2900024I10Rik
    Expression
    Biased expression in frontal lobe adult (RPKM 14.0), CNS E18 (RPKM 9.5) and 14 other tissues See more
    Orthologs

    Genomic context

    See Adcyap1r1 in Genome Data Viewer
    Location:
    6; 6 B3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (55451501..55501455)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (55401974..55451449)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430584L05 gene Neighboring gene growth hormone releasing hormone receptor Neighboring gene predicted gene, 34441 Neighboring gene phosphoglycerate mutase 1 pseudogene Neighboring gene neurogenic differentiation 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP-ribosylation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    vasoactive intestinal polypeptide receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide type I receptor
    Names
    PACAP type I receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025372.2NP_001020543.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001020543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AI843743, AK083108, BC067039, BY286680, CA316040
      Consensus CDS
      CCDS20166.1
      UniProtKB/TrEMBL
      Q6NXJ9
      Related
      ENSMUSP00000066902.5, ENSMUST00000070756.11
      Conserved Domains (2) summary
      pfam00002
      Location:150396
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
    2. NM_007407.4NP_031433.3  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_031433.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI843743, AK083108, BC067039, BY286680, CA320747
      Consensus CDS
      CCDS20167.1
      UniProtKB/Swiss-Prot
      P70205
      UniProtKB/TrEMBL
      Q6NXJ9
      Related
      ENSMUSP00000063784.5, ENSMUST00000070736.11
      Conserved Domains (2) summary
      pfam00002
      Location:150424
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      55451501..55501455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505388.2XP_006505451.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

      See identical proteins and their annotated locations for XP_006505451.1

      Conserved Domains (2) summary
      pfam00002
      Location:150451
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
    2. XM_011241150.1XP_011239452.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

      See identical proteins and their annotated locations for XP_011239452.1

      Related
      ENSMUSP00000126994.1, ENSMUST00000167234.7
      Conserved Domains (2) summary
      pfam00002
      Location:150451
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
    3. XM_011241152.2XP_011239454.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3

      UniProtKB/TrEMBL
      E9Q968
      Related
      ENSMUSP00000130923.1, ENSMUST00000165786.1
      Conserved Domains (2) summary
      pfam00002
      Location:150423
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
    4. XM_011241151.1XP_011239453.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2

      Conserved Domains (2) summary
      pfam00002
      Location:129430
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52116
      HRM; Hormone receptor domain
    5. XM_011241153.2XP_011239455.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X4

      UniProtKB/TrEMBL
      E9Q3E8
      Related
      ENSMUSP00000127319.1, ENSMUST00000172084.7
      Conserved Domains (2) summary
      pfam00002
      Location:129375
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52116
      HRM; Hormone receptor domain
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