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    Adcyap1 adenylate cyclase activating polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 11516, updated on 2-Apr-2019

    Summary

    Official Symbol
    Adcyap1provided by MGI
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by MGI
    Primary source
    MGI:MGI:105094
    See related
    Ensembl:ENSMUSG00000024256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PACAP
    Summary
    This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in CNS E18 (RPKM 2.0), CNS E14 (RPKM 1.8) and 6 other tissues See more
    Orthologs

    Genomic context

    See Adcyap1 in Genome Data Viewer
    Location:
    17; 17 E5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (93198908..93206541)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (93598762..93604831)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene predicted gene, 32465 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene PWP1 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pituitary adenylate cyclase activating polypeptide activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pituitary adenylate cyclase activating polypeptide activity ISO
    Inferred from Sequence Orthology
    more info
     
    pituitary adenylate cyclase-activating polypeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    histamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of acute inflammatory response to non-antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of oligodendrocyte progenitor proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001315503.1NP_001302432.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC154798, AK079530, BY130819
      Consensus CDS
      CCDS29029.1
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q3UYH8, Q8BJT8
      Related
      ENSMUSP00000157279.1, ENSMUST00000234081.1
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone
    2. NM_001315504.1NP_001302433.1  pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK079530, BC057344, BY718488
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q8BJT8
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone
    3. NM_009625.3NP_033755.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK079530, BC057344, BY718488
      Consensus CDS
      CCDS29029.1
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q3UYH8, Q8BJT8
      Related
      ENSMUSP00000067057.6, ENSMUST00000064775.7
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      93198908..93206541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523498.3XP_006523561.1  pituitary adenylate cyclase-activating polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006523561.1

      Conserved Domains (1) summary
      pfam00123
      Location:150176
      Hormone_2; Peptide hormone
    2. XM_006523499.3XP_006523562.1  pituitary adenylate cyclase-activating polypeptide isoform X2

      Conserved Domains (1) summary
      pfam00123
      Location:123149
      Hormone_2; Peptide hormone
    3. XM_017317212.1XP_017172701.1  pituitary adenylate cyclase-activating polypeptide isoform X3

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