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    Casp4 caspase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114555, updated on 18-Apr-2019

    Summary

    Official Symbol
    Casp4provided by RGD
    Official Full Name
    caspase 4provided by RGD
    Primary source
    RGD:621757
    See related
    Ensembl:ENSRNOG00000033697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Casp11
    Summary
    cysteine-aspartic acid protease (caspase); involved with the terminal stage of apoptosis; may also be involved with response to inflammation [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Spleen (RPKM 162.6), Thymus (RPKM 161.5) and 9 other tissues See more

    Genomic context

    See Casp4 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (2616391..2651682)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (2638624..2673915)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351646 Neighboring gene caspase 1 Neighboring gene uncharacterized LOC102557277 Neighboring gene caspase 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    General gene information

    Homology

    Clone Names

    • MGC124949

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ectopic germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    ectopic germ cell programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-1 beta secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    pyroptosis IEA
    Inferred from Electronic Annotation
    more info
     
    pyroptosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    caspase 4
    Names
    caspase 11
    caspase 4, apoptosis-related cysteine peptidase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053736.2NP_446188.2  caspase 4

      See identical proteins and their annotated locations for NP_446188.2

      Status: PROVISIONAL

      Source sequence(s)
      BC104720
      UniProtKB/TrEMBL
      Q3MHS1
      Related
      ENSRNOP00000058685.4, ENSRNOT00000061973.4
      Conserved Domains (2) summary
      smart00115
      Location:122371
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:585
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      2616391..2651682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      4218310..4234223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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