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    Acp5 acid phosphatase 5, tartrate resistant [ Mus musculus (house mouse) ]

    Gene ID: 11433, updated on 31-Jan-2019

    Summary

    Official Symbol
    Acp5provided by MGI
    Official Full Name
    acid phosphatase 5, tartrate resistantprovided by MGI
    Primary source
    MGI:MGI:87883
    See related
    Ensembl:ENSMUSG00000001348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRAP; TRACP
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 123.7), colon adult (RPKM 116.7) and 17 other tissues See more
    Orthologs

    Genomic context

    See Acp5 in Genome Data Viewer
    Location:
    9 A3; 9 8.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (22126727..22135746, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (21931171..21940190, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene microRNA 7084 Neighboring gene ELF1 homolog, elongation factor 1 Neighboring gene predicted gene, 39306 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Y-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    tartrate-resistant acid phosphatase type 5
    Names
    TR-AP
    acid phosphatase type V
    tartrate-resistant acid ATPase
    trATPase
    type 5 acid phosphatase
    NP_001095874.1
    NP_001095875.1
    NP_031414.1
    XP_006510007.1
    XP_006510008.1
    XP_006510009.1
    XP_011240686.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102404.1NP_001095874.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001095874.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AK010865, AK011915, BQ031772, BY084869
      Consensus CDS
      CCDS22923.1
      UniProtKB/Swiss-Prot
      Q05117
      Related
      ENSMUSP00000065425.6, ENSMUST00000069330.13
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    2. NM_001102405.1NP_001095875.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001095875.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AK010865, AK011915, BQ031772, BY107232
      Consensus CDS
      CCDS22923.1
      UniProtKB/Swiss-Prot
      Q05117
      Related
      ENSMUSP00000127128.1, ENSMUST00000165735.8
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    3. NM_007388.3NP_031414.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_031414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AK010865, AK011915, BG076865, BQ031772
      Consensus CDS
      CCDS22923.1
      UniProtKB/Swiss-Prot
      Q05117
      Related
      ENSMUSP00000110970.2, ENSMUST00000115315.2
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      22126727..22135746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242384.2XP_011240686.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_011240686.1

      UniProtKB/Swiss-Prot
      Q05117
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    2. XM_006509944.3XP_006510007.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_006510007.1

      UniProtKB/Swiss-Prot
      Q05117
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    3. XM_006509945.2XP_006510008.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_006510008.1

      UniProtKB/Swiss-Prot
      Q05117
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    4. XM_006509946.1XP_006510009.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_006510009.1

      UniProtKB/Swiss-Prot
      Q05117
      Related
      ENSMUSP00000149597.1, ENSMUST00000213815.1
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
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