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    Gpx5 glutathione peroxidase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113919, updated on 18-Apr-2019

    Summary

    Symbol
    Gpx5provided by RGD
    Full Name
    glutathione peroxidase 5provided by RGD
    Primary source
    RGD:69227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    enzyme that catalyzes the reduction of lipid peroxides; has a role in the hydrogen peroxide scavenging system found within the epididymis [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 13.3) See more
    Orthologs

    Genomic context

    See Gpx5 in Genome Data Viewer
    Location:
    17q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (45508657..45518686)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (57952807..57962120, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene transfer RNA threonine (anticodon UGU)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sperm plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    sperm plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    epididymal secretory glutathione peroxidase
    Names
    EGLP
    GPx-5
    GSHPx-5
    epididymis-specific glutathione peroxidase-like protein
    NP_001099208.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105738.1NP_001099208.1  epididymal secretory glutathione peroxidase precursor

      See identical proteins and their annotated locations for NP_001099208.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474072
      UniProtKB/Swiss-Prot
      P30710
      Conserved Domains (1) summary
      cd00340
      Location:39211
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      45508657..45518686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      53035706..53042631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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