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    Srsf1 serine/arginine-rich splicing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 110809, updated on 31-Jan-2019

    Summary

    Official Symbol
    Srsf1provided by MGI
    Official Full Name
    serine/arginine-rich splicing factor 1provided by MGI
    Primary source
    MGI:MGI:98283
    See related
    Ensembl:ENSMUSG00000018379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asf; Sf2; Sfrs1; AI482334; AW491331; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 77.9), CNS E14 (RPKM 62.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Srsf1 in Genome Data Viewer
    Location:
    11 C; 11 52.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (88046763..88053757)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (87861173..87867259)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 2 Neighboring gene predicted gene, 38610 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA topoisomerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RS domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA splicing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA 5'-splice site recognition ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 1
    Names
    ASF/SF2
    pre-mRNA-splicing factor SRp30a
    splicing factor, arginine/serine-rich 1 (ASF/SF2)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078167.2NP_001071635.1  serine/arginine-rich splicing factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001071635.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK053674, AK078715, AL593853, CF739274
      Consensus CDS
      CCDS36274.1
      UniProtKB/Swiss-Prot
      Q6PDM2
      Related
      ENSMUSP00000133517.1, ENSMUST00000079866.10
      Conserved Domains (3) summary
      COG0724
      Location:888
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12597
      Location:1790
      RRM1_SRSF1; RNA recognition motif 1 in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cl17169
      Location:121190
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_173374.4NP_775550.2  serine/arginine-rich splicing factor 1 isoform 1

      See identical proteins and their annotated locations for NP_775550.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK053674, AL593853, CF739274
      Consensus CDS
      CCDS36273.1
      UniProtKB/Swiss-Prot
      Q6PDM2
      Related
      ENSMUSP00000120595.2, ENSMUST00000139129.8
      Conserved Domains (2) summary
      cd12597
      Location:1790
      RRM1_SRSF1; RNA recognition motif 1 in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cd12601
      Location:121193
      RRM2_SRSF1_like; RNA recognition motif 2 in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      88046763..88053757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388324.3 RNA Sequence

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_004450260.1 Reference GRCm38.p4 PATCHES

      Range
      52797..59181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187003.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1186479..1192857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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