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    AFDN afadin, adherens junction formation factor [ Nomascus leucogenys (northern white-cheeked gibbon) ]

    Gene ID: 100592208, updated on 19-Jan-2018

    Summary

    Gene symbol
    AFDN
    Gene description
    afadin, adherens junction formation factor
    See related
    Ensembl:ENSNLEG00000000333
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nomascus leucogenys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
    Orthologs

    Genomic context

    See AFDN in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    102 current Nleu_3.0 (GCF_000146795.2) 3 NC_019818.1 (155348392..155456701)

    Chromosome 3 - NC_019818.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency-associated protein 4 pseudogene Neighboring gene uncharacterized LOC101179038 Neighboring gene kinesin family member 25 Neighboring gene FERM domain containing 1

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_019818.1 Chromosome 3 Reference Nleu_3.0

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    General gene information

    Markers

    Homology

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Nleu_3.0

    Genomic

    1. NC_019818.1 Reference Nleu_3.0

      Range
      155348392..155456701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012505959.1XP_012361413.1  afadin

      Related
      ENSNLEP00000040812.1, ENSNLET00000044329.1
      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570891
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9671049
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
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