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    afdn afadin, adherens junction formation factor [ Anolis carolinensis (green anole) ]

    Gene ID: 100564963, updated on 5-Aug-2017

    Summary

    Gene symbol
    afdn
    Gene description
    afadin, adherens junction formation factor
    See related
    Ensembl:ENSACAG00000008269
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Anolis carolinensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Iguania; Dactyloidae; Anolis
    Orthologs

    Genomic context

    See afdn in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    102 current AnoCar2.0 (GCF_000090745.1) 1 NC_014776.1 (224947802..225058596, complement)

    Chromosome 1 - NC_014776.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing 1 Neighboring gene kinesin family member 25 Neighboring gene protein unc-93 homolog A Neighboring gene uncharacterized LOC107983917 Neighboring gene tubulin tyrosine ligase like 2

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_014776.1 Chromosome 1 Reference AnoCar2.0 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    General protein information

    Preferred Names
    afadin
    Names
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Anolis carolinensis Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference AnoCar2.0 Primary Assembly

    Genomic

    1. NC_014776.1 Reference AnoCar2.0 Primary Assembly

      Range
      224947802..225058596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016999369.1XP_016854858.1  afadin isoform X5

    2. XM_008124676.2XP_008122883.1  afadin isoform X3

      Conserved Domains (5) summary
      cd01781
      Location:251350
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:421503
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10171099
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:25136
      UBQ; Ubiquitin-like proteins
    3. XM_008124670.2XP_008122877.1  afadin isoform X2

      Conserved Domains (5) summary
      cd01781
      Location:251350
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:25137
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:421503
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10171099
      PDZ; PDZ domain (Also known as DHR or GLGF)
    4. XM_008124681.2XP_008122888.1  afadin isoform X4

      Conserved Domains (5) summary
      cd01781
      Location:252351
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:25137
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:422504
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:613935
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10111093
      PDZ; PDZ domain (Also known as DHR or GLGF)
    5. XM_008124665.2XP_008122872.1  afadin isoform X1

      Conserved Domains (5) summary
      cd01781
      Location:252351
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:25137
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:422504
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:613942
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10181100
      PDZ; PDZ domain (Also known as DHR or GLGF)
    6. XM_008124725.2XP_008122932.1  afadin isoform X11

      Conserved Domains (5) summary
      cd01781
      Location:250349
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:387487
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:596918
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9941076
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:25136
      UBQ; Ubiquitin-like proteins
    7. XM_008124711.2XP_008122918.1  afadin isoform X10

      Conserved Domains (5) summary
      cd01781
      Location:250349
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:387487
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:596918
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9941076
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:25136
      UBQ; Ubiquitin-like proteins
    8. XM_008124706.2XP_008122913.1  afadin isoform X9

      Related
      ENSACAP00000008247.3, ENSACAT00000008424.3
      Conserved Domains (5) summary
      cd01781
      Location:251350
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:421503
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612934
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10101092
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:25136
      UBQ; Ubiquitin-like proteins
    9. XM_008124700.2XP_008122907.1  afadin isoform X8

      Conserved Domains (5) summary
      cd01781
      Location:252351
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:25137
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:389489
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:598927
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10031085
      PDZ; PDZ domain (Also known as DHR or GLGF)
    10. XM_008124693.2XP_008122900.1  afadin isoform X7

      Related
      ENSACAP00000022051.1, ENSACAT00000029469.1
      Conserved Domains (5) summary
      cd01781
      Location:252351
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:25137
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:422504
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:613942
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10181100
      PDZ; PDZ domain (Also known as DHR or GLGF)
    11. XM_008124687.2XP_008122894.1  afadin isoform X6

      Conserved Domains (5) summary
      cd01781
      Location:252351
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:25137
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:422504
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:613942
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10181100
      PDZ; PDZ domain (Also known as DHR or GLGF)
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