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    AFDN afadin, adherens junction formation factor [ Sus scrofa (pig) ]

    Gene ID: 100514741, updated on 2-Oct-2018

    Summary

    Gene symbol
    AFDN
    Gene description
    afadin, adherens junction formation factor
    See related
    Ensembl:ENSSSCG00000004018
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in lung (RPKM 25.5), kidney (RPKM 14.9) and 8 other tissues See more
    Orthologs

    Genomic context

    See AFDN in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (1569652..1698475, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (2720204..2814551, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene FERM domain containing 1 Neighboring gene kinesin family member 25 Neighboring gene microRNA mir-9824 Neighboring gene uncharacterized LOC102166504 Neighboring gene uncharacterized LOC106506295

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    General protein information

    Preferred Names
    afadin
    Names
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      1569652..1698475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021085839.1XP_020941498.1  afadin isoform X16

      Conserved Domains (6) summary
      cd01781
      Location:246345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9921074
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14811643
      DUF4670; Domain of unknown function (DUF4670)
    2. XM_013984302.2XP_013839756.1  afadin isoform X15

      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570891
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9671049
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    3. XM_021085815.1XP_020941474.1  afadin isoform X10

      Conserved Domains (6) summary
      cd01781
      Location:246345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9921074
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14811655
      DUF4670; Domain of unknown function (DUF4670)
    4. XM_021085803.1XP_020941462.1  afadin isoform X8

      Conserved Domains (6) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14971671
      DUF4670; Domain of unknown function (DUF4670)
    5. XM_021085787.1XP_020941446.1  afadin isoform X5

      Conserved Domains (6) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:15051679
      DUF4670; Domain of unknown function (DUF4670)
    6. XM_021085831.1XP_020941490.1  afadin isoform X13

      Conserved Domains (6) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14971659
      DUF4670; Domain of unknown function (DUF4670)
    7. XM_021085833.1XP_020941492.1  afadin isoform X14

      Conserved Domains (5) summary
      cd01781
      Location:42141
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:212294
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:406734
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:810892
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:12991473
      DUF4670; Domain of unknown function (DUF4670)
    8. XM_021085776.1XP_020941435.1  afadin isoform X4

      Conserved Domains (6) summary
      cd01781
      Location:204303
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:374456
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:568896
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9721054
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:189
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:14611635
      DUF4670; Domain of unknown function (DUF4670)
    9. XM_013984277.2XP_013839731.1  afadin isoform X3

      Conserved Domains (5) summary
      cd01781
      Location:205304
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:375457
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:569897
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9731055
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:189
      UBQ; Ubiquitin-like proteins
    10. XM_013984272.2XP_013839726.1  afadin isoform X2

      Conserved Domains (5) summary
      cd01781
      Location:205304
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:375457
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:569897
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9731055
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    11. XM_013984289.2XP_013839743.1  afadin isoform X9

      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:343443
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:555883
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9591041
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    12. XM_013984278.2XP_013839732.1  afadin isoform X6

      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570891
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9671049
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    13. XM_021085824.1XP_020941483.1  afadin isoform X12

      Conserved Domains (6) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570898
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9741056
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:14631625
      DUF4670; Domain of unknown function (DUF4670)
    14. XM_013984285.2XP_013839739.1  afadin isoform X7

      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570898
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9741056
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    15. XM_013984267.2XP_013839721.1  afadin isoform X1

      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570898
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9741056
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    16. XM_013984296.2XP_013839750.1  afadin isoform X11

      Conserved Domains (5) summary
      cd01781
      Location:206305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570898
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9741056
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:190
      UBQ; Ubiquitin-like proteins
    17. XM_021085843.1XP_020941502.1  afadin isoform X17

      Related
      ENSSSCP00000032558.1, ENSSSCT00000039396.1
      Conserved Domains (5) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
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