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    PIAS3 protein inhibitor of activated STAT 3 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100461795, updated on 9-Oct-2018

    Summary

    Gene symbol
    PIAS3
    Gene description
    protein inhibitor of activated STAT 3
    Locus tag
    CR201_G0041165
    See related
    Ensembl:ENSPPYG00000000934
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs

    Genomic context

    See PIAS3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Susie_PABv2 (GCF_002880775.1) 1 NC_036903.1 (105738748..105750063)
    102 previous assembly P_pygmaeus_2.0.2 (GCF_000001545.4) 1 NC_012591.1 (105802644..105814181)

    Chromosome 1 - NC_036903.1Genomic Context describing neighboring genes Neighboring gene neuroblastoma breakpoint family member 10-like Neighboring gene ankyrin repeat domain 35 Neighboring gene integrin subunit alpha 10 Neighboring gene nudix hydrolase 17 Neighboring gene RNA polymerase III subunit C Neighboring gene ring finger protein 115

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pongo abelii Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Susie_PABv2 Primary Assembly

    Genomic

    1. NC_036903.1 Reference Susie_PABv2 Primary Assembly

      Range
      105738748..105750063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009245153.2XP_009243428.1  E3 SUMO-protein ligase PIAS3 isoform X2

      UniProtKB/TrEMBL
      H2N628
      Related
      ENSPPYP00000001087
      Conserved Domains (3) summary
      smart00513
      Location:227
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:314362
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:117254
      PINIT; PINIT domain
    2. XM_009245155.2XP_009243430.1  E3 SUMO-protein ligase PIAS3 isoform X3

      Conserved Domains (3) summary
      smart00513
      Location:1136
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:126263
      PINIT; PINIT domain
      cl17238
      Location:330352
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. XM_002810321.3XP_002810367.1  E3 SUMO-protein ligase PIAS3 isoform X1

      Conserved Domains (2) summary
      pfam14324
      Location:128272
      PINIT; PINIT domain
      cd16790
      Location:324371
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
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