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    PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100453085, updated on 9-Oct-2018

    Summary

    Gene symbol
    PIK3CG
    Gene description
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
    Locus tag
    CR201_G0036697
    See related
    Ensembl:ENSPPYG00000017896
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs

    Genomic context

    See PIK3CG in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Susie_PABv2 (GCF_002880775.1) 7 NC_036910.1 (92286660..92328204)
    102 previous assembly P_pygmaeus_2.0.2 (GCF_000001545.4) 7 NC_012598.1 (103000780..103042676)

    Chromosome 7 - NC_036910.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103891190 Neighboring gene coiled-coil domain containing 71 like Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene HMG-box transcription factor 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Inositol phosphate metabolism, organism-specific biosystem (from KEGG)
      Inositol phosphate metabolism, organism-specific biosystem
      Inositol phosphate metabolism
    • Inositol phosphate metabolism, conserved biosystem (from KEGG)
      Inositol phosphate metabolism, conserved biosystem
      Inositol phosphate metabolism
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Names
    phosphoinositide-3-kinase, catalytic, gamma polypeptide

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pongo abelii Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Susie_PABv2 Primary Assembly

    Genomic

    1. NC_036910.1 Reference Susie_PABv2 Primary Assembly

      Range
      92286660..92328204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002818336.3XP_002818382.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    2. XM_002818335.3XP_002818381.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    3. XM_002818334.3XP_002818380.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
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