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    SYK spleen associated tyrosine kinase [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100345556, updated on 3-Apr-2017

    Summary

    Gene symbol
    SYK
    Gene description
    spleen associated tyrosine kinase
    See related
    Ensembl:ENSOCUG00000017539
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs

    Genomic context

    See SYK in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    102 current OryCun2.0 (GCF_000003625.3) 1 NC_013669.1 (77228028..77325313, complement)

    Chromosome 1 - NC_013669.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103348611 Neighboring gene uncharacterized LOC108178545 Neighboring gene inorganic pyrophosphatase 2, mitochondrial pseudogene Neighboring gene DIRAS family GTPase 2

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_013669.1 Chromosome 1 Reference OryCun2.0 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen tyrosine kinase

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference OryCun2.0 Primary Assembly

    Genomic

    1. NC_013669.1 Reference OryCun2.0 Primary Assembly

      Range
      77228028..77325313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008257989.2XP_008256211.1  tyrosine-protein kinase SYK isoform X2

      Conserved Domains (4) summary
      cd05116
      Location:345601
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:344596
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_008257975.2XP_008256197.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_008256197.1

      UniProtKB/TrEMBL
      G1TDW9
      Related
      ENSOCUP00000015068.3, ENSOCUT00000017541.3
      Conserved Domains (4) summary
      cd05116
      Location:368624
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:367619
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_002708262.3XP_002708308.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_002708308.1

      UniProtKB/TrEMBL
      G1TDW9
      Conserved Domains (4) summary
      cd05116
      Location:368624
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:367619
      Pkinase_Tyr; Protein tyrosine kinase
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