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    IL12RB1 interleukin 12 receptor subunit beta 1 [ Sus scrofa (pig) ]

    Gene ID: 100271900, updated on 8-Dec-2018

    Summary

    Gene symbol
    IL12RB1
    Gene description
    interleukin 12 receptor subunit beta 1
    See related
    Ensembl:ENSSSCG00000013894
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in spleen (RPKM 3.5), lung (RPKM 1.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See IL12RB1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (59707958..59736282)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (59276610..59305011)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106507302 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene uncharacterized LOC110259319 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene uncharacterized LOC106507304 Neighboring gene arrestin domain containing 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Interleukin-12 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
      Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
      Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

    General protein information

    Preferred Names
    interleukin-12 receptor subunit beta-1
    Names
    IL12 receptor beta 1 subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145986.1NP_001139458.1  interleukin-12 receptor subunit beta-1 precursor

      See identical proteins and their annotated locations for NP_001139458.1

      Status: PROVISIONAL

      Source sequence(s)
      AB490071
      UniProtKB/TrEMBL
      B9X2I5
      Related
      ENSSSCP00000014774.1, ENSSSCT00000015180.2
      Conserved Domains (1) summary
      pfam00041
      Location:451536
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      59707958..59736282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013987467.2XP_013842921.1  interleukin-12 receptor subunit beta-1 isoform X1

      Conserved Domains (1) summary
      pfam00041
      Location:452537
      fn3; Fibronectin type III domain
    2. XM_021077206.1XP_020932865.1  interleukin-12 receptor subunit beta-1 isoform X2

      Conserved Domains (1) summary
      pfam00041
      Location:325410
      fn3; Fibronectin type III domain
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