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    CLOCK clock circadian regulator [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100172630, updated on 7-Oct-2018

    Summary

    Gene symbol
    CLOCK
    Gene description
    clock circadian regulator
    Locus tag
    CR201_G0043214
    See related
    Ensembl:ENSPPYG00000014762
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs

    Genomic context

    See CLOCK in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Susie_PABv2 (GCF_002880775.1) 4 NC_036907.1 (62024353..62142823)
    102 previous assembly P_pygmaeus_2.0.2 (GCF_000001545.4) 4 NC_012595.1 (64554928..64666766)

    Chromosome 4 - NC_036907.1Genomic Context describing neighboring genes Neighboring gene neuromedin U Neighboring gene phosducin like 2 Neighboring gene transmembrane protein 165 Neighboring gene uncharacterized LOC112133141 Neighboring gene uncharacterized LOC103890420

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Circadian rhythm, organism-specific biosystem (from KEGG)
      Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm, conserved biosystem (from KEGG)
      Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp469L011

    General protein information

    Preferred Names
    circadian locomoter output cycles protein kaput
    Names
    clock homolog
    NP_001125706.1
    XP_024101324.1
    XP_024101325.1
    XP_024101326.1
    XP_024101327.1
    XP_024101328.1
    XP_024101329.1
    XP_024101330.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001132234.1NP_001125706.1  circadian locomoter output cycles protein kaput

      See identical proteins and their annotated locations for NP_001125706.1

      Status: PROVISIONAL

      Source sequence(s)
      CR859007
      UniProtKB/Swiss-Prot
      Q5RAK8
      Related
      ENSPPYP00000016487, ENSPPYT00000017160
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam13426
      Location:119220
      PAS_9; PAS domain
      pfam14598
      Location:274377
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Pongo abelii Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Susie_PABv2 Primary Assembly

    Genomic

    1. NC_036907.1 Reference Susie_PABv2 Primary Assembly

      Range
      62024353..62142823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024245558.1XP_024101326.1  circadian locomoter output cycles protein kaput isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    2. XM_024245557.1XP_024101325.1  circadian locomoter output cycles protein kaput isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    3. XM_024245556.1XP_024101324.1  circadian locomoter output cycles protein kaput isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    4. XM_024245562.1XP_024101330.1  circadian locomoter output cycles protein kaput isoform X2

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    5. XM_024245559.1XP_024101327.1  circadian locomoter output cycles protein kaput isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    6. XM_024245560.1XP_024101328.1  circadian locomoter output cycles protein kaput isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    7. XM_024245561.1XP_024101329.1  circadian locomoter output cycles protein kaput isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
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