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    CLOCK clock circadian regulator [ Ovis aries (sheep) ]

    Gene ID: 100171391, updated on 9-Feb-2019

    Summary

    Gene symbol
    CLOCK
    Gene description
    clock circadian regulator
    See related
    Ensembl:ENSOARG00000001602
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs

    Genomic context

    See CLOCK in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Oar_rambouillet_v1.0 (GCF_002742125.1) 6 NC_040257.1 (78022481..78146741, complement)
    102 previous assembly Oar_v4.0 (GCF_000298735.2) 6 NC_019463.2 (70783114..70907400, complement)

    Chromosome 6 - NC_040257.1Genomic Context describing neighboring genes Neighboring gene steroid 5 alpha-reductase 3 Neighboring gene transmembrane protein 165 Neighboring gene phosducin like 2 Neighboring gene neuromedin U

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sheep Tissue Atlas
    • Description: Sheep total RNA was extracted from embryonic and adult tissues
    • BioProject: PRJEB6169
    • Publication: PMID 24904168
    • Analysis date: Mon Jan 29 09:33:46 2018

    Pathways from BioSystems

    • Circadian rhythm, organism-specific biosystem (from KEGG)
      Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm, conserved biosystem (from KEGG)
      Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

    General protein information

    Preferred Names
    circadian locomoter output cycles protein kaput
    Names
    clock homolog
    NP_001124404.1
    XP_012034726.1
    XP_012034728.1
    XP_014951728.1
    XP_014951729.1
    XP_027826517.1
    XP_027826518.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130932.1NP_001124404.1  circadian locomoter output cycles protein kaput

      See identical proteins and their annotated locations for NP_001124404.1

      Status: PROVISIONAL

      Source sequence(s)
      EU016223
      UniProtKB/TrEMBL
      B3SZS4
      Related
      ENSOARP00000001690, ENSOART00000001733
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam13426
      Location:119220
      PAS_9; PAS domain
      pfam14598
      Location:274377
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Ovis aries Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Oar_rambouillet_v1.0 Primary Assembly

    Genomic

    1. NC_040257.1 Reference Oar_rambouillet_v1.0 Primary Assembly

      Range
      78022481..78146741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012179336.3XP_012034726.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_012034726.1

      UniProtKB/TrEMBL
      W5NU46
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam13426
      Location:119220
      PAS_9; PAS domain
      pfam14598
      Location:274377
      PAS_11; PAS domain
    2. XM_027970716.1XP_027826517.1  circadian locomoter output cycles protein kaput isoform X2

    3. XM_015096242.2XP_014951728.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      W5NU46
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam13426
      Location:119220
      PAS_9; PAS domain
      pfam14598
      Location:274377
      PAS_11; PAS domain
    4. XM_015096243.2XP_014951729.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      W5NU46
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam13426
      Location:119220
      PAS_9; PAS domain
      pfam14598
      Location:274377
      PAS_11; PAS domain
    5. XM_012179338.3XP_012034728.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_012034728.1

      UniProtKB/TrEMBL
      W5NU46
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam13426
      Location:119220
      PAS_9; PAS domain
      pfam14598
      Location:274377
      PAS_11; PAS domain
    6. XM_027970717.1XP_027826518.1  circadian locomoter output cycles protein kaput isoform X3

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