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    thbs1 thrombospondin 1 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100170153, updated on 20-Jun-2018

    Summary

    Official Symbol
    thbs1provided by Xenbase
    Official Full Name
    thrombospondin 1provided by Xenbase
    Primary source
    Xenbase:XB-GENE-486189
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    tsp; thbs; tsp1; tsp-1; thbs-1
    Orthologs

    Genomic context

    See thbs1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (98501300..98515014)
    102 previous assembly Xtropicalis_v7 (GCF_000004195.2) Unplaced Scaffold NW_004668241.1 (98225834..98239548)

    Chromosome 8 - NC_030684.1Genomic Context describing neighboring genes Neighboring gene fibrinogen-like protein 1-like protein Neighboring gene uncharacterized LOC105948157 Neighboring gene uncharacterized LOC101732796 Neighboring gene fibrous sheath interacting protein 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    General gene information

    Homology

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_tropicalis_v9.1 Primary Assembly

    Genomic

    1. NC_030684.1 Reference Xenopus_tropicalis_v9.1 Primary Assembly

      Range
      98501300..98515014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002937199.3XP_002937245.1  thrombospondin-1

      Conserved Domains (9) summary
      smart00209
      Location:444496
      TSP1; Thrombospondin type 1 repeats
      sd00001
      Location:769791
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:793827
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:697732
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00093
      Location:324378
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:852888
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:9781175
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:656695
      EGF_3; EGF domain
      cl22861
      Location:27227
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
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