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    ABCB4 ATP binding cassette subfamily B member 4 [ Sus scrofa (pig) ]

    Gene ID: 100144586, updated on 2-Oct-2018

    Summary

    Gene symbol
    ABCB4
    Gene description
    ATP binding cassette subfamily B member 4
    See related
    Ensembl:ENSSSCG00000024520
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Also known as
    MDR3; Pgp3
    Expression
    Biased expression in liver (RPKM 23.1), mixtures (RPKM 7.5) and 1 other tissue See more

    Genomic context

    See ABCB4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (93171371..93262124)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (102651665..102741039)

    Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene multidrug resistance protein 1-like Neighboring gene uncharacterized LOC100522818 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1 Neighboring gene carnitine O-octanoyltransferase Neighboring gene transmembrane protein 243 Neighboring gene cyclin D binding myb like transcription factor 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • ABC transporters, organism-specific biosystem (from KEGG)
      ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC transporters, conserved biosystem (from KEGG)
      ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
      ABC-family proteins mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General protein information

    Preferred Names
    phosphatidylcholine translocator ABCB4
    Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 4
    P-glycoprotein class III
    multidrug resistance 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

      Range
      93171371..93262124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013989596.2XP_013845050.1  phosphatidylcholine translocator ABCB4 isoform X1

      UniProtKB/TrEMBL
      I3LV60
      Related
      ENSSSCP00000049416.1, ENSSSCT00000042672.1
      Conserved Domains (3) summary
      cd03249
      Location:10251264
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:11257
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:52336
      ABC_membrane; ABC transporter transmembrane region
    2. XM_021063454.1XP_020919113.1  phosphatidylcholine translocator ABCB4 isoform X2

      Related
      ENSSSCP00000031503.1, ENSSSCT00000043956.1
      Conserved Domains (1) summary
      cl28181
      Location:11231
      AAA; ATPases associated with a variety of cellular activities
    3. XM_021063467.1XP_020919126.1  phosphatidylcholine translocator ABCB4 isoform X11

      Conserved Domains (1) summary
      COG1132
      Location:102571
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    4. XM_021063466.1XP_020919125.1  phosphatidylcholine translocator ABCB4 isoform X10

      Conserved Domains (1) summary
      COG1132
      Location:102568
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    5. XM_005656694.3XP_005656751.1  phosphatidylcholine translocator ABCB4 isoform X1

      UniProtKB/TrEMBL
      I3LV60
      Related
      ENSSSCP00000028012.2, ENSSSCT00000031774.2
      Conserved Domains (3) summary
      cd03249
      Location:10251264
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:11257
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:52336
      ABC_membrane; ABC transporter transmembrane region
    6. XM_021063455.1XP_020919114.1  phosphatidylcholine translocator ABCB4 isoform X2

      Conserved Domains (1) summary
      cl28181
      Location:11231
      AAA; ATPases associated with a variety of cellular activities
    7. XM_021063464.1XP_020919123.1  phosphatidylcholine translocator ABCB4 isoform X9

      Conserved Domains (3) summary
      cd03249
      Location:583822
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:247824
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl25403
      Location:2180
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
    8. XM_021063458.1XP_020919117.1  phosphatidylcholine translocator ABCB4 isoform X5

      Conserved Domains (1) summary
      cl28181
      Location:451139
      AAA; ATPases associated with a variety of cellular activities
    9. XM_021063462.1XP_020919121.1  phosphatidylcholine translocator ABCB4 isoform X9

      Conserved Domains (3) summary
      cd03249
      Location:583822
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:247824
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl25403
      Location:2180
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
    10. XM_021063463.1XP_020919122.1  phosphatidylcholine translocator ABCB4 isoform X9

      Conserved Domains (3) summary
      cd03249
      Location:583822
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:247824
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl25403
      Location:2180
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
    11. XM_021063457.1XP_020919116.1  phosphatidylcholine translocator ABCB4 isoform X4

      Conserved Domains (1) summary
      cl28181
      Location:451165
      AAA; ATPases associated with a variety of cellular activities
    12. XM_021063460.1XP_020919119.1  phosphatidylcholine translocator ABCB4 isoform X7

      Conserved Domains (1) summary
      cl28181
      Location:151075
      AAA; ATPases associated with a variety of cellular activities
    13. XM_021063468.1XP_020919127.1  phosphatidylcholine translocator ABCB4 isoform X12

      Conserved Domains (1) summary
      COG1132
      Location:10476
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    14. XM_021063456.1XP_020919115.1  phosphatidylcholine translocator ABCB4 isoform X3

      Conserved Domains (1) summary
      cl28181
      Location:951193
      AAA; ATPases associated with a variety of cellular activities
    15. XM_021063465.1XP_020919124.1  phosphatidylcholine translocator ABCB4 isoform X9

      Conserved Domains (3) summary
      cd03249
      Location:583822
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:247824
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl25403
      Location:2180
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
    16. XM_021063459.1XP_020919118.1  phosphatidylcholine translocator ABCB4 isoform X6

      Conserved Domains (1) summary
      cl28181
      Location:31101
      AAA; ATPases associated with a variety of cellular activities
    17. XM_021063461.1XP_020919120.1  phosphatidylcholine translocator ABCB4 isoform X8

      Conserved Domains (1) summary
      cl28181
      Location:371046
      AAA; ATPases associated with a variety of cellular activities

    RNA

    1. XR_002335872.1 RNA Sequence

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