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    abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 100136865, updated on 31-Mar-2019

    Summary

    Official Symbol
    abcb4provided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-52
    See related
    Ensembl:ENSDARG00000010936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:172149

    Genomic context

    See abcb4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (28628739..28658341, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (28694116..28723718, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 16 NC_007127.5 (30856984..30887161, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene carnitine O-octanoyltransferase Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene DC-STAMP domain containing 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase-coupled protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    toxin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 4
    Names
    ABC efflux transporter 4
    abcb1b

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114583.2NP_001108055.2  ATP-binding cassette, sub-family B (MDR/TAP), member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CR388365, EH508856, EH534990
      Conserved Domains (3) summary
      cd03249
      Location:397634
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG5265
      Location:154630
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      pfam00664
      Location:60348
      ABC_membrane; ABC transporter transmembrane region
    2. NM_001316714.1NP_001303643.1  ATP-binding cassette, sub-family B (MDR/TAP), member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX322614, CF999615, CR388365, DY562772, EH508856, EH534990
      UniProtKB/TrEMBL
      E7F1E3
      Related
      ENSDARP00000123836.1, ENSDART00000148456.3
      Conserved Domains (3) summary
      cd03249
      Location:397634
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:551266
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:60348
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      28628739..28658341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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