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    AFDN afadin, adherens junction formation factor [ Equus caballus (horse) ]

    Gene ID: 100054846, updated on 14-Jan-2019

    Summary

    Official Symbol
    AFDNprovided by VGNC
    Official Full Name
    afadin, adherens junction formation factorprovided by VGNC
    Primary source
    VGNC:VGNC:15143
    See related
    Ensembl:ENSECAG00000014680
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs

    Genomic context

    See AFDN in Genome Data Viewer
    Location:
    chromosome: 31
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 31 NC_009174.3 (2410277..2550132, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 31 NC_009174.2 (8143546..8240308)

    Chromosome 31 - NC_009174.3Genomic Context describing neighboring genes Neighboring gene FERM domain containing 1 Neighboring gene kinesin family member 25 Neighboring gene unc-93 homolog A Neighboring gene t-complex 10 like 2

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    General protein information

    Preferred Names
    afadin; afadin, adherens junction formation factor
    Names
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009174.3 Reference EquCab3.0 Primary Assembly

      Range
      2410277..2550132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023632879.1XP_023488647.1  afadin isoform X11

      Conserved Domains (7) summary
      cd01781
      Location:246345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:594915
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9911073
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:14321674
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:10891242
      Atrophin-1; Atrophin-1 family
    2. XM_023632877.1XP_023488645.1  afadin isoform X9

      Related
      ENSECAP00000028703.1, ENSECAT00000039755.1
      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610931
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10071089
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:14481678
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11051258
      Atrophin-1; Atrophin-1 family
    3. XM_023632869.1XP_023488637.1  afadin isoform X2

      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610938
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10141096
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:14551697
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11121265
      Atrophin-1; Atrophin-1 family
    4. XM_023632871.1XP_023488639.1  afadin isoform X3

      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610938
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10141096
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14551697
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11121265
      Atrophin-1; Atrophin-1 family
    5. XM_023632876.1XP_023488644.1  afadin isoform X8

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:385485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:596924
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10001082
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14411683
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:10981251
      Atrophin-1; Atrophin-1 family
    6. XM_023632878.1XP_023488646.1  afadin isoform X10

      Related
      ENSECAP00000044933.1, ENSECAT00000031678.1
      Conserved Domains (6) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl26464
      Location:11061259
      Atrophin-1; Atrophin-1 family
    7. XM_023632873.1XP_023488641.1  afadin isoform X5

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14491691
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11061259
      Atrophin-1; Atrophin-1 family
    8. XM_023632875.1XP_023488643.1  afadin isoform X7

      Conserved Domains (6) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl26464
      Location:11131266
      Atrophin-1; Atrophin-1 family
    9. XM_023632874.1XP_023488642.1  afadin isoform X6

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14561686
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11131266
      Atrophin-1; Atrophin-1 family
    10. XM_023632872.1XP_023488640.1  afadin isoform X4

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14561696
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11131266
      Atrophin-1; Atrophin-1 family
    11. XM_023632868.1XP_023488636.1  afadin isoform X1

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14561698
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11131266
      Atrophin-1; Atrophin-1 family
    12. XM_023632880.1XP_023488648.1  afadin isoform X12

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:14561698
      DUF4670; Domain of unknown function (DUF4670)
      cl26464
      Location:11131266
      Atrophin-1; Atrophin-1 family
    13. XM_023632881.1XP_023488649.1  afadin isoform X13

      Related
      ENSECAP00000012677.2, ENSECAT00000015739.2
      Conserved Domains (6) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610931
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10071089
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins
      cl26464
      Location:11051258
      Atrophin-1; Atrophin-1 family
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