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    CLOCK clock circadian regulator [ Monodelphis domestica (gray short-tailed opossum) ]

    Gene ID: 100017022, updated on 17-Apr-2019

    Summary

    Gene symbol
    CLOCK
    Gene description
    clock circadian regulator
    See related
    Ensembl:ENSMODG00000020678
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Monodelphis domestica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
    Orthologs

    Genomic context

    See CLOCK in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    103 current MonDom5 (GCF_000002295.2) 5 NC_008805.1 (170238455..170371504)

    Chromosome 5 - NC_008805.1Genomic Context describing neighboring genes Neighboring gene neuromedin U Neighboring gene phosducin like 2 Neighboring gene transmembrane protein 165 Neighboring gene uncharacterized LOC103100679 Neighboring gene steroid 5 alpha-reductase 3

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_008805.1 Chromosome 5 Reference MonDom5 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Circadian rhythm, organism-specific biosystem (from KEGG)
      Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm, conserved biosystem (from KEGG)
      Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

    General protein information

    Preferred Names
    circadian locomoter output cycles protein kaput
    Names
    clock homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Monodelphis domestica Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference MonDom5 Primary Assembly

    Genomic

    1. NC_008805.1 Reference MonDom5 Primary Assembly

      Range
      170238455..170371504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007496441.2XP_007496503.1  circadian locomoter output cycles protein kaput isoform X2

      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    2. XM_016423240.1XP_016278726.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    3. XM_016423245.1XP_016278731.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    4. XM_016423241.1XP_016278727.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    5. XM_007496440.2XP_007496502.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_007496502.1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    6. XM_016423243.1XP_016278729.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    7. XM_016423242.1XP_016278728.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      F7DL74
      Related
      ENSMODP00000025868.3, ENSMODT00000026330.3
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    8. XM_016423244.1XP_016278730.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    9. XM_007496439.2XP_007496501.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_007496501.1

      UniProtKB/TrEMBL
      F7DL74
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:275373
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam14598
      Location:274377
      PAS_11; PAS domain
    10. XM_007496443.2XP_007496505.1  circadian locomoter output cycles protein kaput isoform X3

      Conserved Domains (2) summary
      cd00130
      Location:150248
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:149252
      PAS_11; PAS domain
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