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    NCF4 neutrophil cytosolic factor 4 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009359, updated on 27-Jan-2018

    Summary

    Gene symbol
    NCF4
    Gene description
    neutrophil cytosolic factor 4
    See related
    Ensembl:ENSOCUG00000021337
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs

    Genomic context

    See NCF4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    102 current OryCun2.0 (GCF_000003625.3) 4 NC_013672.1 (85024945..85038594, complement)

    Chromosome 4 - NC_013672.1Genomic Context describing neighboring genes Neighboring gene testis expressed 33 Neighboring gene colony stimulating factor 2 receptor beta common subunit Neighboring gene uncharacterized LOC108176677 Neighboring gene parvalbumin Neighboring gene intraflagellar transport 27

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_013672.1 Chromosome 4 Reference OryCun2.0 Primary Assembly

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    General protein information

    Preferred Names
    neutrophil cytosol factor 4
    Names
    neutrophil cytosolic factor 4, 40kDa
    p40-phox

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082654.1NP_001076123.1  neutrophil cytosol factor 4

      See identical proteins and their annotated locations for NP_001076123.1

      Status: PROVISIONAL

      Source sequence(s)
      AF323790
      UniProtKB/TrEMBL
      Q95MN1
      Related
      ENSOCUP00000020100.1, ENSOCUT00000029379.2
      Conserved Domains (3) summary
      cd06399
      Location:238330
      PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
      cd06882
      Location:19141
      PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
      cd11869
      Location:174227
      SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

    RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference OryCun2.0 Primary Assembly

    Genomic

    1. NC_013672.1 Reference OryCun2.0 Primary Assembly

      Range
      85024945..85038594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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