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    ERBB3 erb-b2 receptor tyrosine kinase 3 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100008807, updated on 3-Apr-2017

    Summary

    Gene symbol
    ERBB3
    Gene description
    erb-b2 receptor tyrosine kinase 3
    See related
    Ensembl:ENSOCUG00000017322
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs

    Genomic context

    See ERBB3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    102 current OryCun2.0 (GCF_000003625.3) 4 NC_013672.1 (39637792..39661767)

    Chromosome 4 - NC_013672.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 Neighboring gene uncharacterized LOC108176652 Neighboring gene dolichol-phosphate mannosyltransferase subunit 1 pseudogene Neighboring gene proliferation-associated 2G4 Neighboring gene uncharacterized LOC108176694

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_013672.1 Chromosome 4 Reference OryCun2.0 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    receptor tyrosine-protein kinase erbB-3
    Names
    receptor tyrosine kinase ErbB3
    v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference OryCun2.0 Primary Assembly

    Genomic

    1. NC_013672.1 Reference OryCun2.0 Primary Assembly

      Range
      39637792..39661767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002711067.3XP_002711113.1  receptor tyrosine-protein kinase erbB-3 isoform X2

      Related
      ENSOCUP00000014890.2, ENSOCUT00000017328.2
      Conserved Domains (8) summary
      cd05111
      Location:701979
      PTK_HER3; Pseudokinase domain of the Protein Tyrosine Kinase, HER3
      cd12095
      Location:640676
      TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
      smart00261
      Location:548594
      FU; Furin-like repeats
      cd00064
      Location:228268
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:185331
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:355476
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:709965
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:501632
      GF_recep_IV; Growth factor receptor domain IV
    2. XM_008256636.2XP_008254858.1  receptor tyrosine-protein kinase erbB-3 isoform X1

      Conserved Domains (8) summary
      cd05111
      Location:657935
      PTK_HER3; Pseudokinase domain of the Protein Tyrosine Kinase, HER3
      cd12095
      Location:596632
      TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
      smart00261
      Location:504550
      FU; Furin-like repeats
      cd00064
      Location:184224
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:141287
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:311432
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:665921
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:457588
      GF_recep_IV; Growth factor receptor domain IV
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