Format

Send to:

Choose Destination
    • Showing Current items.

    map2k2b mitogen-activated protein kinase kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 100002225, updated on 14-Feb-2019

    Summary

    Official Symbol
    map2k2bprovided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080219-34
    See related
    Ensembl:ENSDARG00000068918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:172250

    Genomic context

    See map2k2b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (57416844..57444145, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (57282690..57309976, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 2 NC_007113.5 (57891760..57919056, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-325m22.2 Neighboring gene uncharacterized LOC108180185 Neighboring gene transcription factor 3a Neighboring gene protein inhibitor of activated STAT, 4b Neighboring gene one cut homeobox 3b

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Homology

    • Homologs of the map2k2b gene: The map2k2b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, and rice.
    • Orthologs

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 2
    NP_001121753.1
    XP_009297220.1
    XP_021333936.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128281.1NP_001121753.1  dual specificity mitogen-activated protein kinase kinase 2

      See identical proteins and their annotated locations for NP_001121753.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155634
      UniProtKB/TrEMBL
      A9JRF0
      Related
      ENSDARP00000090612.2, ENSDART00000099839.3
      Conserved Domains (2) summary
      cd06615
      Location:69382
      PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase
      smart00220
      Location:71364
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      57416844..57444145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478261.1XP_021333936.1  dual specificity mitogen-activated protein kinase kinase 2 isoform X1

      Related
      ENSDARP00000124788.1, ENSDART00000149838.3
      Conserved Domains (1) summary
      cd06615
      Location:69382
      PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase
    2. XM_009298945.3XP_009297220.1  dual specificity mitogen-activated protein kinase kinase 2 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:71265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:69323
      PKc_like; Protein Kinases, catalytic domain
    Support Center