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    App amyloid beta precursor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54226, updated on 22-May-2018
    Official Symbol
    Appprovided by RGD
    Official Full Name
    amyloid beta precursor proteinprovided by RGD
    Primary source
    RGD:2139
    See related
    Ensembl:ENSRNOG00000006997
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abeta
    Summary
    activates voltage dependent calcium channels; may induce neuronal apoptosis [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 1960.2), Lung (RPKM 1647.7) and 9 other tissues See more
    Orthologs
    See App in Genome Data Viewer
    Location:
    11q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24425013..24641872, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (28048897..28265250, complement)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551946 Neighboring gene junctional adhesion molecule 2 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor, alpha subunit Neighboring gene cysteine and tyrosine rich 1 Neighboring gene hypothetical protein LOC681265

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    PTB domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    PTB domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    adult locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    axo-dendritic transport ISO
    Inferred from Sequence Orthology
    more info
     
    NOT axo-dendritic transport ISO
    Inferred from Sequence Orthology
    more info
     
    axo-dendritic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon midline choice point recognition ISO
    Inferred from Sequence Orthology
    more info
     
    axon midline choice point recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular copper ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to norepinephrine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    collateral sprouting in absence of injury ISO
    Inferred from Sequence Orthology
    more info
     
    collateral sprouting in absence of injury ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA polyadenylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    mating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microglia development IEA
    Inferred from Electronic Annotation
    more info
     
    microglia development ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of age-related behavioral decline IEA
    Inferred from Electronic Annotation
    more info
     
    modulation of age-related behavioral decline ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    modulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT negative regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    neuron remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NIK/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of astrocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epidermal growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of multicellular organism growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of spontaneous synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of spontaneous synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse structure or activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse structure or activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    smooth endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    suckling behavior IEA
    Inferred from Electronic Annotation
    more info
     
    suckling behavior ISO
    Inferred from Sequence Orthology
    more info
     
    synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic growth at neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic growth at neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    COPII-coated ER to Golgi transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary rootlet ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    main axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope lumen IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    NOT synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton HDA PubMed 
    Preferred Names
    amyloid-beta A4 protein; amyloid beta A4 protein
    Names
    ABPP
    AG
    alzheimer disease amyloid A4 protein homolog
    amyloid A4
    amyloid beta (A4) precursor protein
    amyloid precursor protein
    amyloidogenic glycoprotein
    beta-amyloid precursor protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019288.2NP_062161.1  amyloid-beta A4 protein precursor

      See identical proteins and their annotated locations for NP_062161.1

      Status: PROVISIONAL

      Source sequence(s)
      AF513015
      UniProtKB/Swiss-Prot
      P08592
      Related
      ENSRNOP00000041613.3, ENSRNOT00000048854.6
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:675713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:716766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      24425013..24641872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248010.3XP_006248072.1  amyloid beta A4 protein isoform X3

      See identical proteins and their annotated locations for XP_006248072.1

      UniProtKB/TrEMBL
      Q6P6Q5
      Related
      ENSRNOP00000040243.4, ENSRNOT00000044081.5
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:638676
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:679729
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    2. XM_006248008.3XP_006248070.1  amyloid beta A4 protein isoform X1

      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:657695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    3. XM_006248012.3XP_006248074.1  amyloid beta A4 protein isoform X5

      Conserved Domains (6) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:582620
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:623673
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
    4. XM_006248011.3XP_006248073.1  amyloid beta A4 protein isoform X4

      See identical proteins and their annotated locations for XP_006248073.1

      UniProtKB/Swiss-Prot
      P08592
      Conserved Domains (6) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:600638
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:641691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
    5. XM_006248009.3XP_006248071.1  amyloid beta A4 protein isoform X2

      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:656694
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:697747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      23853696..24069048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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