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    WISP2 WNT1 inducible signaling pathway protein 2 [ Homo sapiens (human) ]

    Gene ID: 8839, updated on 12-Mar-2017
    Official Symbol
    WISP2provided by HGNC
    Official Full Name
    WNT1 inducible signaling pathway protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12770
    See related
    Ensembl:ENSG00000064205 MIM:603399; Vega:OTTHUMG00000033071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCN5; CT58; CTGF-L
    Summary
    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    20q13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (44714204..44728041)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43343493..43356453)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene adenosine deaminase Neighboring gene long intergenic non-protein coding RNA 1260 Neighboring gene KCNK15 antisense RNA 1 (head to head) Neighboring gene potassium two pore domain channel subfamily K member 15 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene piggyBac transposable element derived 4 pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of WNT1 inducible signaling pathway protein 2 (WISP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    WNT1-inducible-signaling pathway protein 2
    Names
    CCN family member 5
    connective tissue growth factor-like protein
    connective tissue growth factor-related protein 58

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323369.1NP_001310298.1  WNT1-inducible-signaling pathway protein 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) retains an intron in its 5' UTR, and uses an alternate splice site and lacks an alternate exon in its 5' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF083500, AL139352, BC058074, BI823598, BU623413
      Consensus CDS
      CCDS82619.1
      UniProtKB/Swiss-Prot
      O76076
      Related
      ENSP00000361956, OTTHUMP00000063228, ENST00000372865, OTTHUMT00000127825
      Conserved Domains (1) summary
      pfam00219
      Location:4278
      IGFBP; Insulin-like growth factor binding protein
    2. NM_001323370.1NP_001310299.1  WNT1-inducible-signaling pathway protein 2 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL139352, BI823598, BU623413
      Consensus CDS
      CCDS13336.1
      UniProtKB/Swiss-Prot
      O76076
      Related
      ENSP00000361959, OTTHUMP00000063227, ENST00000372868, OTTHUMT00000127824
      Conserved Domains (2) summary
      pfam00219
      Location:4278
      IGFBP; Insulin-like growth factor binding protein
      cl17735
      Location:100160
      VWC; von Willebrand factor type C domain
    3. NM_003881.3NP_003872.1  WNT1-inducible-signaling pathway protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_003872.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) retains an intron in its 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL139352, BC017782, BC058074, BI823598, BU623413
      Consensus CDS
      CCDS13336.1
      UniProtKB/Swiss-Prot
      O76076
      Related
      ENSP00000190983, OTTHUMP00000031770, ENST00000190983, OTTHUMT00000080484
      Conserved Domains (2) summary
      pfam00219
      Location:4278
      IGFBP; Insulin-like growth factor binding protein
      cl17735
      Location:100160
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      44714204..44728041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028117.1XP_016883606.1  WNT1-inducible-signaling pathway protein 2 isoform X2

    2. XM_017028116.1XP_016883605.1  WNT1-inducible-signaling pathway protein 2 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      43246561..43259529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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