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    Glp1r glucagon-like peptide 1 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25051, updated on 6-Aug-2017
    Official Symbol
    Glp1rprovided by RGD
    Official Full Name
    glucagon-like peptide 1 receptorprovided by RGD
    Primary source
    RGD:2703
    See related
    Ensembl:ENSRNOG00000001152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glip; RATGL1RCP
    Summary
    induces insulin secretion; mediates neuroendocrine signaling of feeding behavior; mediates cardiovascular response and increased blood pressure [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9586075..9626228)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (11768479..11808416)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene eukaryotic translation initiation factor 3 subunit I-like Neighboring gene uromodulin-like 1 Neighboring gene ATP binding cassette subfamily G member 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein coupled peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G-protein coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    glucagon receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucagon-like peptide 1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucagon-like peptide 1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    glucagon-like peptide 1 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptide hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    associative learning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of heart contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion TAS
    Traceable Author Statement
    more info
     
    release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    glucagon-like peptide 1 receptor
    Names
    GLP-1 receptor
    GLP-1-R
    GLP-1R
    pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012728.1NP_036860.1  glucagon-like peptide 1 receptor precursor

      See identical proteins and their annotated locations for NP_036860.1

      Status: PROVISIONAL

      Source sequence(s)
      M97797
      UniProtKB/Swiss-Prot
      P32301
      Related
      ENSRNOP00000001527.5, ENSRNOT00000001527.6
      Conserved Domains (2) summary
      pfam00002
      Location:141398
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:59128
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      9586075..9626228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      10499202..10536348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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