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The patterns of synonymous codon and amino acid usages for E2 gene might be caused by the equilibrium of evolutionary forces from virus and host. Our work gave new investigations into the role of host origin in the formations of synonymous codon/amino acid usages and the evolutionary trend of BVDV E2 gene.
Title: The analyses of relationships among nucleotide, synonymous codon and amino acid usages for E2 gene of bovine viral diarrhea virus.
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The crystal structures of the homodimeric glycoprotein E2 from the pestivirus bovine viral diarrhea virus 1 (BVDV1) at both neutral and low pH, are reported.[E2]
Title: Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry.
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Arg283 and Ile287 may be implicated in ribonucleotide binding and positioning of the template base in the active site, while Arg285 appears to be involved directly in the selection of cognate nucleotide.[NS5B]
Title: Residues Arg283, Arg285, and Ile287 in the nucleotide binding pocket of bovine viral diarrhea virus NS5B RNA polymerase affect catalysis and fidelity.
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analysis of the humoral immune response against the prokaryotic expressed N-terminal autoprotease (N(pro)) protein of bovine viral diarrhoea virus [N(pro)]
Title: Evidence of a humoral immune response against the prokaryotic expressed N-terminal autoprotease (N(pro)) protein of bovine viral diarrhoea virus.
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These results show that bovine viral diarrhea virus NS4B is an integral membrane protein associated with the Golgi apparatus and virus-induced membranes, the putative site for BVDV genome replication.
Title: Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes.
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The viral envelope glycoprotein E(rns) inhibits IFN expression induced by extracellular viral ssRNA and dsRNA. [E(rns)]
Title: The viral RNase E(rns) prevents IFN type-I triggering by pestiviral single- and double-stranded RNAs.
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The crystal structure of RdRp containing an Asn438 duplication shows that the "N-terminal domain," which occurs only in pestiviruses such as BVDV, interacts with the polymerase component of the same polypeptide chain. (RdRp)
Title: The structure of bovine viral diarrhea virus RNA-dependent RNA polymerase and its amino-terminal domain.