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    ABCF1 ATP binding cassette subfamily F member 1 [ Homo sapiens (human) ]

    Gene ID: 23, updated on 6-Aug-2017
    Official Symbol
    ABCF1provided by HGNC
    Official Full Name
    ATP binding cassette subfamily F member 1provided by HGNC
    Primary source
    HGNC:HGNC:70
    See related
    Ensembl:ENSG00000204574 MIM:603429; Vega:OTTHUMG00000031094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABC27; ABC50
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6p21.33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (30571393..30591532)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30539170..30559309)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene G protein nucleolar 1 (putative) Neighboring gene proline rich 3 Neighboring gene ABCF1 divergent transcript Neighboring gene microRNA 877 Neighboring gene protein phosphatase 1 regulatory subunit 10 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin, alpha pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, ATP-binding cassette, sub-family F (ABCF1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ABCF1 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    translation TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ATP-binding cassette sub-family F member 1
    Names
    ATP-binding cassette 50 (TNF-alpha stimulated)
    ATP-binding cassette, sub-family F (GCN20), member 1
    TNF-alpha-stimulated ABC protein
    TNFalpha-inducible ATP-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047030.1 RefSeqGene

      Range
      5001..25140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025091.1NP_001020262.1  ATP-binding cassette sub-family F member 1 isoform a

      See identical proteins and their annotated locations for NP_001020262.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF027302, BC034488, BI547952, BM556481, BU620927
      Consensus CDS
      CCDS34380.1
      UniProtKB/Swiss-Prot
      Q8NE71
      UniProtKB/TrEMBL
      A0A1U9X609
      Related
      ENSP00000313603.8, OTTHUMP00000029111, ENST00000326195.12, OTTHUMT00000076137
      Conserved Domains (3) summary
      cd03221
      Location:304525
      ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
      COG0488
      Location:302833
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      cl21455
      Location:697774
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001090.2NP_001081.1  ATP-binding cassette sub-family F member 1 isoform b

      See identical proteins and their annotated locations for NP_001081.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      AF027302, BI547952, BM556481, BU620927
      Consensus CDS
      CCDS34381.1
      UniProtKB/Swiss-Prot
      Q8NE71
      UniProtKB/TrEMBL
      Q2L6I2
      Related
      ENSP00000365728.3, OTTHUMP00000029110, ENST00000376545.7, OTTHUMT00000076136
      Conserved Domains (3) summary
      cd03221
      Location:266487
      ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
      COG0488
      Location:264795
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      cl21455
      Location:659736
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      30571393..30591532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      2051115..2071250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p7 ALT_REF_LOCI_3

      Range
      1827220..1847359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p7 ALT_REF_LOCI_4

      Range
      1881622..1901761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p7 ALT_REF_LOCI_5

      Range
      1915439..1935578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p7 ALT_REF_LOCI_6

      Range
      1826480..1846615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p7 ALT_REF_LOCI_7

      Range
      1872150..1892288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      30541266..30561417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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