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    GTSE1 G2 and S-phase expressed 1 [ Homo sapiens (human) ]

    Gene ID: 51512, updated on 5-Nov-2017
    Official Symbol
    GTSE1provided by HGNC
    Official Full Name
    G2 and S-phase expressed 1provided by HGNC
    Primary source
    HGNC:HGNC:13698
    See related
    Ensembl:ENSG00000075218 MIM:607477; Vega:OTTHUMG00000150486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B99
    Summary
    The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    22q13.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (46295879..46333699)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46692638..46729596)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene polycystin family receptor for egg jelly Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene GTSE1 antisense RNA 1 (head to head) Neighboring gene tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase Neighboring gene cadherin EGF LAG seven-pass G-type receptor 1 Neighboring gene family with sequence similarity 136 member A pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystem (from REACTOME)
      The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystemGTSE1 (B99) was identified as a microtubule-associated protein product of the mouse B99 gene, which exhibits both a cell cycle regulated expression, with highest levels in G2, and DNA damage triggere...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    G2 and S phase-expressed protein 1
    Names
    G-2 and S-phase expressed 1
    protein B99 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016426.6NP_057510.4  G2 and S phase-expressed protein 1

      See identical proteins and their annotated locations for NP_057510.4

      Status: REVIEWED

      Source sequence(s)
      BC006325, BC075828, DB091686
      Consensus CDS
      CCDS14074.2
      UniProtKB/Swiss-Prot
      Q9NYZ3
      Related
      ENSP00000415430.1, OTTHUMP00000197503, ENST00000454366.1, OTTHUMT00000318360
      Conserved Domains (1) summary
      pfam15259
      Location:28171
      GTSE1_N; G-2 and S-phase expressed 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      46295879..46333699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028816.1XP_016884305.1  G2 and S phase-expressed protein 1 isoform X3

      Conserved Domains (1) summary
      pfam15259
      Location:28171
      GTSE1_N; G-2 and S-phase expressed 1
    2. XM_011530213.2XP_011528515.1  G2 and S phase-expressed protein 1 isoform X4

      Conserved Domains (1) summary
      pfam15259
      Location:28171
      GTSE1_N; G-2 and S-phase expressed 1
    3. XM_005261627.3XP_005261684.1  G2 and S phase-expressed protein 1 isoform X1

      Conserved Domains (1) summary
      pfam15259
      Location:28171
      GTSE1_N; G-2 and S-phase expressed 1
    4. XM_011530211.2XP_011528513.1  G2 and S phase-expressed protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15259
      Location:118
      GTSE1_N; G-2 and S-phase expressed 1
    5. XM_017028815.1XP_016884304.1  G2 and S phase-expressed protein 1 isoform X1

      Conserved Domains (1) summary
      pfam15259
      Location:28171
      GTSE1_N; G-2 and S-phase expressed 1

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      46651368..46685447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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