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    VCP valosin containing protein [ Homo sapiens (human) ]

    Gene ID: 7415, updated on 6-Aug-2017
    Official Symbol
    VCPprovided by HGNC
    Official Full Name
    valosin containing proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12666
    See related
    Ensembl:ENSG00000165280 MIM:601023; Vega:OTTHUMG00000019855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p97; TERA; ALS14; CDC48; CMT2Y; IBMPFD; HEL-220; IBMPFD1; HEL-S-70
    Summary
    The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (35056068..35072742, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35056065..35072739, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 131 Neighboring gene RNA, 7SL, cytoplasmic 338, pseudogene Neighboring gene Fanconi anemia complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with valosin containing protein (VCP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpu vpu A functional ER-associated degradation pathway is required for Vpu-induced tetherin degradation. P97 ATPase (VCP) knockdown partially impairs Vpu-mediated tetherin degradation PubMed
    vpu The VCP-UFD1L-NPL4 complex is required for HIV-1 Vpu-induced CD4 degradation in the ER-associated degradation pathway. The ATPase activity of VCP and ubiquitin binding to UFD1L are important for CD4 degradation by Vpu PubMed

    Go to the HIV-1, Human Interaction Database

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    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
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      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
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      HRD1/SEL1 ERAD complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
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      Hedgehog ligand biogenesis, organism-specific biosystemMammalian genomes encode three Hedgehog ligands, Sonic Hedgehog (SHH), Indian Hedgehog (IHH) and Desert Hedgehog (DHH). These secreted morphogens can remain associated with lipid rafts on the surfac...
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      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: FANCG

    Homology

    Clone Names

    • MGC8560, MGC131997, MGC148092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    BAT3 complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    K48-linked polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    MHC class I protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deubiquitinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ER to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    ER-associated misfolded protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NADH metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aggresome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum stress-induced pre-emptive quality control IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    endosome to lysosome transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    error-free translesion synthesis TAS
    Traceable Author Statement
    more info
     
    establishment of protein localization TAS
    Traceable Author Statement
    more info
    PubMed 
    flavin adenine dinucleotide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Lys63-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ubiquitin-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein N-linked glycosylation via asparagine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
     
    protein hexamerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein methylation TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein ubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    ubiquitin-dependent ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    ATPase complex IEA
    Inferred from Electronic Annotation
    more info
     
    Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    VCP-NPL4-UFD1 AAA ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    VCP-NPL4-UFD1 AAA ATPase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    VCP-NSFL1C complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transitional endoplasmic reticulum ATPase
    Names
    15S Mg(2+)-ATPase p97 subunit
    TER ATPase
    epididymis luminal protein 220
    epididymis secretory protein Li 70
    yeast Cdc48p homolog
    NP_009057.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007887.1 RefSeqGene

      Range
      5001..21675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_657

    mRNA and Protein(s)

    1. NM_007126.3NP_009057.1  transitional endoplasmic reticulum ATPase

      See identical proteins and their annotated locations for NP_009057.1

      Status: REVIEWED

      Source sequence(s)
      AI343015, BC007562, BC110913, DA880782, DB524539
      Consensus CDS
      CCDS6573.1
      UniProtKB/Swiss-Prot
      P55072
      UniProtKB/TrEMBL
      Q96IF9, V9HW80
      Related
      ENSP00000351777.6, OTTHUMP00000021326, ENST00000358901.10, OTTHUMT00000052290
      Conserved Domains (6) summary
      smart01072
      Location:131191
      CDC48_2; Cell division protein 48 (CDC48) domain 2
      TIGR01243
      Location:25764
      CDC48; AAA family ATPase, CDC48 subfamily
      pfam00004
      Location:241370
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam02359
      Location:25107
      CDC48_N; Cell division protein 48 (CDC48), N-terminal domain
      pfam09336
      Location:718760
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:452534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      35056068..35072742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      35055907..35072605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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