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    Arntl aryl hydrocarbon receptor nuclear translocator-like [ Mus musculus (house mouse) ]

    Gene ID: 11865, updated on 19-Nov-2017
    Official Symbol
    Arntlprovided by MGI
    Official Full Name
    aryl hydrocarbon receptor nuclear translocator-likeprovided by MGI
    Primary source
    MGI:MGI:1096381
    See related
    Ensembl:ENSMUSG00000055116 Vega:OTTMUSG00000060257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOP3; Arnt3; Bmal1; BMAL1b; bHLHe5; bmal1b'
    Summary
    The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
    Orthologs
    Location:
    7 F1; 7 59.17 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (113178470..113314126)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (120350979..120457636)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930543E12 gene Neighboring gene predicted gene, 33659 Neighboring gene predicted gene, 33721 Neighboring gene BTB (POZ) domain containing 10 Neighboring gene parathyroid hormone

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding transcription factor activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
    Inferred by Curator
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal process involved in parturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucocorticoid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus, translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of hair cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of type B pancreatic cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to redox state IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromatoid body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    aryl hydrocarbon receptor nuclear translocator-like protein 1
    Names
    brain and muscle ARNT-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243048.1NP_001229977.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001229977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC156605, AK147145, BQ030833
      Consensus CDS
      CCDS85390.1
      UniProtKB/Swiss-Prot
      Q9WTL8
      UniProtKB/TrEMBL
      Q3UHZ2
      Related
      ENSMUSP00000147764.1, OTTMUSP00000076763, ENSMUST00000210074.1, OTTMUST00000147503
      Conserved Domains (3) summary
      smart00091
      Location:136195
      PAS; PAS domain
      pfam00010
      Location:61113
      HLH; Helix-loop-helix DNA-binding domain
      cl25986
      Location:326428
      PAS_3; PAS fold
    2. NM_001357070.1NP_001343999.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate, in-frame splice site in the 3' coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AC156605, BQ030833
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      pfam00010
      Location:74126
      HLH; Helix-loop-helix DNA-binding domain
      cl25986
      Location:338440
      PAS_3; PAS fold
    3. NM_007489.4NP_031515.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_031515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
      Source sequence(s)
      AC156605, AK147145, BQ030833
      Consensus CDS
      CCDS40092.1
      UniProtKB/Swiss-Prot
      Q9WTL8
      UniProtKB/TrEMBL
      Q3UHZ2
      Related
      ENSMUSP00000046235.7, OTTMUSP00000076762, ENSMUST00000047321.8, OTTMUST00000147502
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      pfam00010
      Location:74126
      HLH; Helix-loop-helix DNA-binding domain
      cl25986
      Location:339441
      PAS_3; PAS fold

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      113178470..113314126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507246.3XP_006507309.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507309.1

      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:348443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:346448
      PAS_11; PAS domain
    2. XM_006507245.2XP_006507308.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507308.1

      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:348443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:346448
      PAS_11; PAS domain
    3. XM_006507249.2XP_006507312.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X2

      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:347442
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:345447
      PAS_11; PAS domain
    4. XM_011241656.2XP_011239958.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011239958.1

      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:348443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:346448
      PAS_11; PAS domain
    5. XM_006507248.2XP_006507311.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507311.1

      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:348443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:346448
      PAS_11; PAS domain
    6. XM_006507252.2XP_006507315.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X5

      Conserved Domains (5) summary
      smart00091
      Location:149208
      PAS; PAS domain
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:74126
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    7. XM_006507253.2XP_006507316.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X6

      Conserved Domains (5) summary
      smart00091
      Location:149208
      PAS; PAS domain
      cd00130
      Location:340435
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:74126
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:338440
      PAS_11; PAS domain
    8. XM_006507250.2XP_006507313.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GS77
      Related
      ENSMUSP00000147823.1, OTTMUSP00000076765, ENSMUST00000211770.1, OTTMUST00000147505
      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:348443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:346448
      PAS_11; PAS domain
    9. XM_006507251.2XP_006507314.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006507314.1

      UniProtKB/Swiss-Prot
      Q9WTL8
      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:347442
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:345447
      PAS_11; PAS domain
    10. XM_017321949.1XP_017177438.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X7

      UniProtKB/Swiss-Prot
      Q9WTL8
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      pfam00010
      Location:74126
      HLH; Helix-loop-helix DNA-binding domain
      cl25986
      Location:338440
      PAS_3; PAS fold
    11. XM_017321950.1XP_017177439.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X7

      UniProtKB/Swiss-Prot
      Q9WTL8
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      pfam00010
      Location:74126
      HLH; Helix-loop-helix DNA-binding domain
      cl25986
      Location:338440
      PAS_3; PAS fold
    12. XM_006507247.3XP_006507310.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507310.1

      Conserved Domains (5) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd00130
      Location:348443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:81133
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:153260
      PAS; PAS fold
      pfam14598
      Location:346448
      PAS_11; PAS domain

    RNA

    1. XR_001785467.1 RNA Sequence

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