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    DMBT1 deleted in malignant brain tumors 1 [ Homo sapiens (human) ]

    Gene ID: 1755, updated on 5-Nov-2017
    Official Symbol
    DMBT1provided by HGNC
    Official Full Name
    deleted in malignant brain tumors 1provided by HGNC
    Primary source
    HGNC:HGNC:2926
    See related
    Ensembl:ENSG00000187908 MIM:601969; Vega:OTTHUMG00000019185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAG; GP340; SALSA; muclin
    Summary
    Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]
    Orthologs
    Location:
    10q26.13
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (122560665..122643736)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124320181..124403252)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378525 Neighboring gene age-related maculopathy susceptibility 2 Neighboring gene uncharacterized LOC105378526 Neighboring gene HtrA serine peptidase 1 Neighboring gene chromosome 10 open reading frame 120 Neighboring gene deleted in malignant brain tumors 1 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Aalanine substitution scan reveals amino acids D34, D35, N96, and E101 in gp340 are the critical residues interaction with HIV-1 gp120 PubMed
    env HIV-1 gp120 binds peptides (residues 21-40, 66-85, and 91-109) derived from the first scavenger receptor cysteine rich domain (SRCR1) of gp340 with relative high affinity binding activity PubMed
    env A 35KDa purified recombinant N-terminal protein of gp340 (SAG) interacts with the V3 domain of HIV-1 gp120 PubMed
    env The interaction of gp340 (SAG) with HIV-1 gp120 is enhanced by prebinding of sCD4 to gp120, suggesting that gp340 inhibitory activity is mediated by blocking access of gp120 to its chemokine coreceptor PubMed
    env Salivary agglutinin (SAG), a high molecular weight glycoprotein (340 kDa), binds to HIV-1 gp120; SAG binding to gp120 is Ca(2+) dependent and specifically inhibits HIV-1 infectivity PubMed

    Go to the HIV-1, Human Interaction Database

    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Surfactant metabolism, organism-specific biosystem (from REACTOME)
      Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ61058, MGC164738

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium-dependent protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scavenger receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    scavenger receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling pattern recognition receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    zymogen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    epithelial cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    induction of bacterial agglutination TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zymogen granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    deleted in malignant brain tumors 1 protein
    Names
    glycoprotein 340
    gp-340
    hensin
    salivary agglutinin
    salivary scavenger and agglutinin
    surfactant pulmonary-associated D-binding protein
    vomeroglandin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012644.1 RefSeqGene

      Range
      5001..88072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320644.1NP_001307573.1  deleted in malignant brain tumors 1 protein isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 2. The encoded isoform (d) is shorter than isoform b.
      Source sequence(s)
      AJ243212, AJ297935, AL603764, BX640988
      UniProtKB/Swiss-Prot
      Q9UGM3
      Conserved Domains (6) summary
      smart00042
      Location:17751874
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21262378
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20072115
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22322378
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    2. NM_004406.2NP_004397.2  deleted in malignant brain tumors 1 protein isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks multiple in-frame exons in the coding region compared to variant 2. The encoded isoform (a) is shorter than isoform b.
      Source sequence(s)
      AJ297935, AL603764
      Consensus CDS
      CCDS44491.1
      UniProtKB/Swiss-Prot
      Q9UGM3
      Related
      ENSP00000357952.2, ENST00000368956.6
      Conserved Domains (5) summary
      smart00202
      Location:494594
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:14991751
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:11381248
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:16051751
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:499594
      SRCR; Scavenger receptor cysteine-rich domain
    3. NM_007329.2NP_015568.2  deleted in malignant brain tumors 1 protein isoform b precursor

      See identical proteins and their annotated locations for NP_015568.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (b).
      Source sequence(s)
      AJ297935, AL603764
      Consensus CDS
      CCDS44490.1
      UniProtKB/Swiss-Prot
      Q9UGM3
      Related
      ENSP00000357905.3, ENST00000368909.7
      Conserved Domains (6) summary
      smart00042
      Location:17751874
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21272379
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20082116
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22332379
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    4. NM_017579.2NP_060049.2  deleted in malignant brain tumors 1 protein isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform b.
      Source sequence(s)
      AJ297935, AL603764
      Consensus CDS
      CCDS44492.1
      UniProtKB/Swiss-Prot
      Q9UGM3
      Related
      ENSP00000357951.3, ENST00000368955.7
      Conserved Domains (6) summary
      smart00042
      Location:17651864
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9831083
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21172369
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:19982106
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22232369
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:728823
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      122560665..122643736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539415.2XP_011537717.1  deleted in malignant brain tumors 1 protein isoform X27

      Conserved Domains (5) summary
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:14801732
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:11191229
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:15861732
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    2. XM_011539405.2XP_011537707.1  deleted in malignant brain tumors 1 protein isoform X18

      See identical proteins and their annotated locations for XP_011537707.1

      UniProtKB/Swiss-Prot
      Q9UGM3
      Conserved Domains (6) summary
      smart00042
      Location:17751874
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21272379
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20082116
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22332379
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    3. XM_011539388.2XP_011537690.1  deleted in malignant brain tumors 1 protein isoform X1

      UniProtKB/Swiss-Prot
      Q9UGM3
      Conserved Domains (6) summary
      smart00042
      Location:19042003
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22562508
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21372245
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23622508
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    4. XM_011539389.2XP_011537691.1  deleted in malignant brain tumors 1 protein isoform X2

      Conserved Domains (6) summary
      smart00042
      Location:19042003
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22552507
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21362244
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23612507
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    5. XM_011539410.2XP_011537712.1  deleted in malignant brain tumors 1 protein isoform X22

      Conserved Domains (6) summary
      smart00042
      Location:17731872
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21252377
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20062114
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22312377
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    6. XM_011539403.2XP_011537705.1  deleted in malignant brain tumors 1 protein isoform X17

      Conserved Domains (6) summary
      smart00042
      Location:17751874
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21272379
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20082116
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22332379
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    7. XM_011539395.2XP_011537697.1  deleted in malignant brain tumors 1 protein isoform X8

      Conserved Domains (6) summary
      smart00042
      Location:18941993
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22462498
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21272235
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23522498
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    8. XM_011539394.2XP_011537696.1  deleted in malignant brain tumors 1 protein isoform X7

      Related
      ENSP00000484603.1, ENST00000619379.1
      Conserved Domains (6) summary
      smart00042
      Location:18941993
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22462498
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21272235
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23522498
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    9. XM_011539393.2XP_011537695.1  deleted in malignant brain tumors 1 protein isoform X6

      Related
      ENSP00000342210.3, OTTHUMP00000020654, ENST00000338354.7, OTTHUMT00000050792
      Conserved Domains (6) summary
      smart00042
      Location:18941993
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22462498
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21272235
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23522498
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    10. XM_011539392.2XP_011537694.1  deleted in malignant brain tumors 1 protein isoform X3

      Conserved Domains (6) summary
      smart00042
      Location:18941993
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9931093
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22462498
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21272235
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23522498
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    11. XM_011539390.2XP_011537692.1  deleted in malignant brain tumors 1 protein isoform X4

      Conserved Domains (6) summary
      smart00042
      Location:18941993
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9831083
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22462498
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21272235
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23522498
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    12. XM_011539409.2XP_011537711.1  deleted in malignant brain tumors 1 protein isoform X20

      Conserved Domains (6) summary
      smart00042
      Location:17731872
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:733833
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21252377
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20062114
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22312377
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    13. XM_011539407.2XP_011537709.1  deleted in malignant brain tumors 1 protein isoform X19

      Conserved Domains (6) summary
      smart00042
      Location:17731872
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:862962
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21252377
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20062114
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22312377
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    14. XM_011539401.2XP_011537703.1  deleted in malignant brain tumors 1 protein isoform X15

      Conserved Domains (6) summary
      smart00042
      Location:17751874
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:864964
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21272379
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20082116
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22332379
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    15. XM_011539411.2XP_011537713.1  deleted in malignant brain tumors 1 protein isoform X23

      Conserved Domains (6) summary
      smart00042
      Location:17651864
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:854954
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21172369
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:19982106
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22232369
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    16. XM_011539400.2XP_011537702.1  deleted in malignant brain tumors 1 protein isoform X14

      Conserved Domains (6) summary
      smart00042
      Location:17961895
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:885985
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21482400
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20292137
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22542400
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:630725
      SRCR; Scavenger receptor cysteine-rich domain
    17. XM_011539391.2XP_011537693.1  deleted in malignant brain tumors 1 protein isoform X5

      UniProtKB/Swiss-Prot
      Q9UGM3
      Related
      ENSP00000343175.3, OTTHUMP00000020661, ENST00000344338.7, OTTHUMT00000050799
      Conserved Domains (6) summary
      smart00042
      Location:18941993
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9831083
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22462498
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21272235
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23522498
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:728823
      SRCR; Scavenger receptor cysteine-rich domain
    18. XM_011539408.2XP_011537710.1  deleted in malignant brain tumors 1 protein isoform X21

      Conserved Domains (6) summary
      smart00042
      Location:17731872
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:862962
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21252377
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20062114
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22312377
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:607702
      SRCR; Scavenger receptor cysteine-rich domain
    19. XM_011539398.2XP_011537700.1  deleted in malignant brain tumors 1 protein isoform X11

      Conserved Domains (6) summary
      smart00042
      Location:18831982
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9721072
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22352487
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21162224
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23412487
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:717812
      SRCR; Scavenger receptor cysteine-rich domain
    20. XM_011539402.2XP_011537704.1  deleted in malignant brain tumors 1 protein isoform X16

      Conserved Domains (6) summary
      smart00042
      Location:17751874
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:864964
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:21272379
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:20082116
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:22332379
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:609704
      SRCR; Scavenger receptor cysteine-rich domain
    21. XM_006717660.3XP_006717723.1  deleted in malignant brain tumors 1 protein isoform X9

      Conserved Domains (6) summary
      smart00042
      Location:18881987
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9771077
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22402492
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21212229
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23462492
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:722817
      SRCR; Scavenger receptor cysteine-rich domain
    22. XM_011539399.2XP_011537701.1  deleted in malignant brain tumors 1 protein isoform X12

      Conserved Domains (6) summary
      smart00042
      Location:18721971
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9611061
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22242476
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21052213
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23302476
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:706801
      SRCR; Scavenger receptor cysteine-rich domain
    23. XM_011539396.2XP_011537698.1  deleted in malignant brain tumors 1 protein isoform X10

      Conserved Domains (6) summary
      smart00042
      Location:18881987
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9771077
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22402492
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21212229
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23462492
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:722817
      SRCR; Scavenger receptor cysteine-rich domain
    24. XM_006717665.3XP_006717728.1  deleted in malignant brain tumors 1 protein isoform X13

      Conserved Domains (6) summary
      smart00042
      Location:18721971
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:9611061
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:22242476
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:21052213
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:23302476
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:706801
      SRCR; Scavenger receptor cysteine-rich domain
    25. XM_011539413.2XP_011537715.1  deleted in malignant brain tumors 1 protein isoform X24

      Conserved Domains (6) summary
      smart00042
      Location:16441743
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00202
      Location:733833
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:19962248
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:18771985
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:21022248
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:738833
      SRCR; Scavenger receptor cysteine-rich domain
    26. XM_011539414.2XP_011537716.1  deleted in malignant brain tumors 1 protein isoform X26

      Conserved Domains (5) summary
      smart00202
      Location:492592
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:14971749
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:11361246
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:16031749
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:12651356
      SRCR; Scavenger receptor cysteine-rich domain
    27. XM_017015798.1XP_016871287.1  deleted in malignant brain tumors 1 protein isoform X25

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      124604802..124685026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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