Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    SKA1 spindle and kinetochore associated complex subunit 1 [ Homo sapiens (human) ]

    Gene ID: 220134, updated on 7-May-2017
    Official Symbol
    SKA1provided by HGNC
    Official Full Name
    spindle and kinetochore associated complex subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:28109
    See related
    Ensembl:ENSG00000154839 MIM:616673; Vega:OTTHUMG00000132685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C18orf24
    Orthologs
    Location:
    18q21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (50375022..50394168)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47901392..47920538)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 458 Neighboring gene uncharacterized LOC105372114 Neighboring gene uncharacterized LOC105372115 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 11

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC10200

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule polymerization or depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    condensed chromosome outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    spindle and kinetochore-associated protein 1
    Names
    spindle and KT (kinetochore) associated 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039535.2NP_001034624.1  spindle and kinetochore-associated protein 1

      See identical proteins and their annotated locations for NP_001034624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC105227, BC015606, BC015706, BU659790, BX956145, CN403719
      Consensus CDS
      CCDS11946.1
      UniProtKB/Swiss-Prot
      Q96BD8
      UniProtKB/TrEMBL
      A0A024R294
      Related
      ENSP00000381470.1, OTTHUMP00000262768, ENST00000398452.6, OTTHUMT00000448579
      Conserved Domains (1) summary
      pfam07160
      Location:17246
      DUF1395; Protein of unknown function (DUF1395)
    2. NM_145060.3NP_659497.1  spindle and kinetochore-associated protein 1

      See identical proteins and their annotated locations for NP_659497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC105227, BC015606, BC015706, BU659790, BX956145
      Consensus CDS
      CCDS11946.1
      UniProtKB/Swiss-Prot
      Q96BD8
      UniProtKB/TrEMBL
      A0A024R294
      Related
      ENSP00000285116.3, OTTHUMP00000163540, ENST00000285116.7, OTTHUMT00000255982
      Conserved Domains (1) summary
      pfam07160
      Location:17246
      DUF1395; Protein of unknown function (DUF1395)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

      Range
      50375022..50394168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NW_003315956.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      82829..101975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      47896963..47916096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center