Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Ptn pleiotrophin [ Mus musculus (house mouse) ]

    Gene ID: 19242, updated on 23-May-2018
    Official Symbol
    Ptnprovided by MGI
    Official Full Name
    pleiotrophinprovided by MGI
    Primary source
    MGI:MGI:97804
    See related
    Ensembl:ENSMUSG00000029838 Vega:OTTMUSG00000056195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OSF; HARP; HBBM; HBBN; HBNF; Osf1; Osf-1; HB-GAM; HBGF-8
    Expression
    Biased expression in CNS E18 (RPKM 106.8), frontal lobe adult (RPKM 95.9) and 7 other tissues See more
    Orthologs
    See Ptn in Genome Data Viewer
    Location:
    6 B1; 6 15.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (36714924..36811361, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (36665663..36761361, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, muscarinic 2, cardiac Neighboring gene microRNA 490 Neighboring gene predicted gene 2189 Neighboring gene diacylglycerol kinase, iota Neighboring gene predicted pseudogene 7452 Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene predicted gene, 33275

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chondroitin sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    chondroitin sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycosaminoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparan sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bone mineralization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of skeletal muscle acetylcholine-gated channel clustering ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    retinal rod cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    pleiotrophin
    Names
    heparin-binding brain mitogen
    heparin-binding growth factor 8
    heparin-binding growth-associated molecule
    heparin-binding neutrophic factor
    osteoblast-specific factor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008973.3NP_032999.1  pleiotrophin precursor

      See identical proteins and their annotated locations for NP_032999.1

      Status: VALIDATED

      Source sequence(s)
      AI838962, AK011346, AK011699
      Consensus CDS
      CCDS20005.1
      UniProtKB/Swiss-Prot
      P63089
      Related
      ENSMUSP00000099073.1, OTTMUSP00000072973, ENSMUST00000101534.4
      Conserved Domains (1) summary
      cl02505
      Location:47131
      PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      36714924..36811361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505757.3XP_006505820.2  pleiotrophin isoform X1

      See identical proteins and their annotated locations for XP_006505820.2

      UniProtKB/Swiss-Prot
      P63089
      Conserved Domains (1) summary
      cl02505
      Location:47131
      PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
    Support Center