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    Irak1 interleukin-1 receptor-associated kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 16179, updated on 20-May-2018
    Official Symbol
    Irak1provided by MGI
    Official Full Name
    interleukin-1 receptor-associated kinase 1provided by MGI
    Primary source
    MGI:MGI:107420
    See related
    Ensembl:ENSMUSG00000031392 Vega:OTTMUSG00000017687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S; AA408924
    Expression
    Ubiquitous expression in adrenal adult (RPKM 73.0), ovary adult (RPKM 47.6) and 27 other tissues See more
    Orthologs
    See Irak1 in Genome Data Viewer
    Location:
    X A7.3; X 37.61 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (74013914..74023921, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71259253..71269260, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene host cell factor C1 Neighboring gene predicted gene 8545 Neighboring gene microRNA 5132 Neighboring gene microRNA 718 Neighboring gene methyl CpG binding protein 2 Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) Neighboring gene predicted gene 6758

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    activation of NF-kappaB-inducing kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    interleukin-1-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptidoglycan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    toll-like receptor 4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    type I interferon signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    interleukin-1 receptor-associated kinase 1
    Names
    interleukin-1 receptor-associated kinase-1b
    pelle-like protein kinase
    NP_001171444.1
    NP_001171445.1
    NP_001171446.1
    NP_001171447.1
    NP_032389.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177973.1NP_001171444.1  interleukin-1 receptor-associated kinase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK143694, AL672002
      Consensus CDS
      CCDS53105.1
      UniProtKB/TrEMBL
      B1AUW6, Q8BR10
      Related
      ENSMUSP00000033769.8, OTTMUSP00000019683, ENSMUST00000033769.14, OTTMUST00000043841
      Conserved Domains (3) summary
      smart00221
      Location:219514
      STYKc; Protein kinase; unclassified specificity
      cd08794
      Location:17100
      Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
      cl21453
      Location:219514
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001177974.1NP_001171445.1  interleukin-1 receptor-associated kinase 1 isoform 4

      See identical proteins and their annotated locations for NP_001171445.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
      Source sequence(s)
      AL672002, BP760087, U56773
      Consensus CDS
      CCDS30219.2
      UniProtKB/Swiss-Prot
      Q62406
      UniProtKB/TrEMBL
      Q540G0
      Related
      ENSMUSP00000064448.5, OTTMUSP00000020303, ENSMUST00000068286.11, OTTMUST00000045161
      Conserved Domains (3) summary
      smart00221
      Location:218518
      STYKc; Protein kinase; unclassified specificity
      cd08794
      Location:17100
      Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
      cl21453
      Location:218521
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001177975.1NP_001171446.1  interleukin-1 receptor-associated kinase 1 isoform 3

      See identical proteins and their annotated locations for NP_001171446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK143694, AL672002, BY729815
      Consensus CDS
      CCDS53104.1
      UniProtKB/TrEMBL
      Q8BR10
      Related
      ENSMUSP00000109994.3, OTTMUSP00000019270, ENSMUST00000114354.9, OTTMUST00000042885
      Conserved Domains (3) summary
      smart00221
      Location:219519
      STYKc; Protein kinase; unclassified specificity
      cd08794
      Location:17100
      Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
      cl21453
      Location:219522
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001177976.1NP_001171447.1  interleukin-1 receptor-associated kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001171447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL672002, BP760087, U56773
      Consensus CDS
      CCDS53103.1
      UniProtKB/Swiss-Prot
      Q62406
      Related
      ENSMUSP00000110000.3, OTTMUSP00000020304, ENSMUST00000114360.9, OTTMUST00000045162
      Conserved Domains (3) summary
      smart00221
      Location:218518
      STYKc; Protein kinase; unclassified specificity
      cd08794
      Location:17100
      Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
      cl21453
      Location:218521
      PKc_like; Protein Kinases, catalytic domain
    5. NM_008363.2NP_032389.2  interleukin-1 receptor-associated kinase 1 isoform 4

      See identical proteins and their annotated locations for NP_032389.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
      Source sequence(s)
      AF103876, AL672002
      Consensus CDS
      CCDS30219.2
      UniProtKB/Swiss-Prot
      Q62406
      UniProtKB/TrEMBL
      Q540G0
      Related
      ENSMUSP00000109992.1, OTTMUSP00000019684, ENSMUST00000114352.7, OTTMUST00000043842
      Conserved Domains (3) summary
      smart00221
      Location:218518
      STYKc; Protein kinase; unclassified specificity
      cd08794
      Location:17100
      Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
      cl21453
      Location:218521
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      74013914..74023921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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