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    Htr2c 5-hydroxytryptamine receptor 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25187, updated on 12-Mar-2017
    Official Symbol
    Htr2cprovided by RGD
    Official Full Name
    5-hydroxytryptamine receptor 2Cprovided by RGD
    Primary source
    RGD:2848
    See related
    Ensembl:ENSRNOG00000030877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5-HT2C; 5HT-1C; 5-HTR2C
    Summary
    Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    Location:
    Xq34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (118084520..118318040)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (118226113..118460830)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene similar to eukaryotic translation initiation factor 4B Neighboring gene similar to Actin, cytoplasmic 2 (Gamma-actin) Neighboring gene microRNA 3552 Neighboring gene microRNA 1912 Neighboring gene microRNA 764 Neighboring gene microRNA 1298 Neighboring gene microRNA 448 Neighboring gene zinc finger protein 32-like Neighboring gene interleukin 13 receptor subunit alpha 2

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IEA
    Inferred from Electronic Annotation
    more info
     
    1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled serotonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Gq/11-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Gq/11-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Gq/11-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serotonin binding IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    G-protein coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    inositol phosphate-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase C-activating serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase C-activating serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase C-activating serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase D-activating G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of acetylcholine secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gamma-aminobutyric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of corticotropin-releasing hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of corticotropin-releasing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of corticotropin-releasing hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neurological system process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neurological system process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurological system process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    5-hydroxytryptamine receptor 2C
    Names
    5-HT-1C
    5-HT1C
    5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    5-hydroxytryptamine receptor 1C
    serotonin 1c receptor
    serotonin receptor 2C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012765.3NP_036897.2  5-hydroxytryptamine receptor 2C

      See identical proteins and their annotated locations for NP_036897.2

      Status: REVIEWED

      Source sequence(s)
      AABR03120427, AABR03120814, AABR03124501, BF285550, BF409467, BF415855, CB557712, CB613191, CB784937, U35315
      UniProtKB/Swiss-Prot
      P08909
      UniProtKB/TrEMBL
      Q62842
      Related
      ENSRNOP00000060345, ENSRNOT00000065293
      Conserved Domains (2) summary
      pfam00001
      Location:71370
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:64248
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      118084520..118318040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601920.1XP_017457409.1  5-hydroxytryptamine receptor 2C isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      109958913..110179824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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