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    Abca7 ATP-binding cassette, sub-family A (ABC1), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 27403, updated on 5-Dec-2017
    Official Symbol
    Abca7provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family A (ABC1), member 7provided by MGI
    Primary source
    MGI:MGI:1351646
    See related
    Ensembl:ENSMUSG00000035722 Vega:OTTMUSG00000032606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ABCX; Abc51
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. Defects in this gene cause an increase in amyloid-beta deposits in a mouse model of Alzheimer's disease, and a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in spleen adult (RPKM 30.2), thymus adult (RPKM 29.6) and 26 other tissues See more
    Orthologs
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (79996455..80015572)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79460360..79478317)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, NMDA3B Neighboring gene transmembrane protein 259 Neighboring gene calponin 2 Neighboring gene Rho GTPase activating protein 45 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide E

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apolipoprotein A-I receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apolipoprotein A-I receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine-translocating ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine-translocating ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apolipoprotein A-I-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of amyloid precursor protein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of amyloid-beta formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of amyloid-beta formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phospholipid efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ATP-binding cassette sub-family A member 7

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347081.1NP_001334010.1  ATP-binding cassette sub-family A member 7 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC151846, AC161120, BC036566
      Consensus CDS
      CCDS83724.1
      UniProtKB/TrEMBL
      E9Q6G4
    2. NM_013850.1NP_038878.1  ATP-binding cassette sub-family A member 7 isoform 2

      See identical proteins and their annotated locations for NP_038878.1

      Status: REVIEWED

      Source sequence(s)
      AF287141
      Consensus CDS
      CCDS24004.1
      UniProtKB/Swiss-Prot
      Q91V24
      Related
      ENSMUSP00000043090.7, ENSMUST00000043866.7
      Conserved Domains (2) summary
      TIGR01257
      Location:12120
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:18072027
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      79996455..80015572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513714.2XP_006513777.1  ATP-binding cassette sub-family A member 7 isoform X7

      Conserved Domains (4) summary
      cd03263
      Location:8041023
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      TIGR03864
      Location:8031028
      PQQ_ABC_ATP; ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system
      pfam12698
      Location:547670
      ABC2_membrane_3; ABC-2 family transporter protein
      cl21474
      Location:556668
      ABC2_membrane; ABC-2 type transporter
    2. XM_006513713.3XP_006513776.1  ATP-binding cassette sub-family A member 7 isoform X6

      Conserved Domains (4) summary
      cd03263
      Location:8041023
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      TIGR03864
      Location:8031028
      PQQ_ABC_ATP; ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system
      pfam12698
      Location:547670
      ABC2_membrane_3; ABC-2 family transporter protein
      cl21474
      Location:556668
      ABC2_membrane; ABC-2 type transporter
    3. XM_006513712.3XP_006513775.1  ATP-binding cassette sub-family A member 7 isoform X5

      Conserved Domains (3) summary
      cd03263
      Location:8041023
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      TIGR03864
      Location:8031028
      PQQ_ABC_ATP; ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system
      pfam12698
      Location:14501628
      ABC2_membrane_3; ABC-2 family transporter protein
    4. XM_006513710.1XP_006513773.1  ATP-binding cassette sub-family A member 7 isoform X1

      Related
      ENSMUSP00000128121.1, ENSMUST00000171637.7
      Conserved Domains (2) summary
      TIGR01257
      Location:12128
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:18152035
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    5. XM_006513711.1XP_006513774.1  ATP-binding cassette sub-family A member 7 isoform X3

      Conserved Domains (2) summary
      TIGR01257
      Location:12117
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:18042024
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    6. XM_017313957.1XP_017169446.1  ATP-binding cassette sub-family A member 7 isoform X2

      UniProtKB/Swiss-Prot
      Q91V24
      Related
      ENSMUSP00000115111.1, OTTMUSP00000043312, ENSMUST00000132517.7, OTTMUST00000081084
      Conserved Domains (2) summary
      TIGR01257
      Location:12120
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:18072027
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    7. XM_017313958.1XP_017169447.1  ATP-binding cassette sub-family A member 7 isoform X4

    RNA

    1. XR_380403.2 RNA Sequence

    2. XR_380402.2 RNA Sequence

    3. XR_001779531.1 RNA Sequence

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