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    SCARB1 scavenger receptor class B member 1 [ Homo sapiens (human) ]

    Gene ID: 949, updated on 24-Sep-2017
    Official Symbol
    SCARB1provided by HGNC
    Official Full Name
    scavenger receptor class B member 1provided by HGNC
    Primary source
    HGNC:HGNC:1664
    See related
    Ensembl:ENSG00000073060 MIM:601040; Vega:OTTHUMG00000168544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
    Summary
    The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
    Orthologs
    Location:
    12q24.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (124777628..124863973, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125262174..125348519, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor corepressor 2 Neighboring gene uncharacterized LOC105370047 Neighboring gene uncharacterized LOC101927436 Neighboring gene uncharacterized LOC105370050 Neighboring gene uncharacterized LOC107984444 Neighboring gene uncharacterized LOC105370051 Neighboring gene RNA, U6 small nuclear 927, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    High density lipoprotein cholesterol level quantitative trait locus 6
    MedGen: C1853096 OMIM: 610762 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
    NHGRI GWA Catalog
    Genome-wide association study identifies common variants associated with circulating vitamin E levels.
    NHGRI GWA Catalog
    Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
    NHGRI GWA Catalog
    Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SCARB1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Fat digestion and absorption, organism-specific biosystem (from KEGG)
      Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fat digestion and absorption, conserved biosystem (from KEGG)
      Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Folate Metabolism, organism-specific biosystem (from WikiPathways)
      Folate Metabolism, organism-specific biosystem
      Folate Metabolism
    • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
      HDL-mediated lipid transport, organism-specific biosystemHDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and e...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
      Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
      Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
      Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Scavenging by Class B Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class B Receptors, organism-specific biosystemClass B receptors have two transmembrane domains separated by an extracellular loop (reviewed in Adachi and Tsujimoto 2006, Areschoug and Gordon 2009).
    • Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
      Selenium Micronutrient Network, organism-specific biosystem
      Selenium Micronutrient Network
    • Statin Pathway, organism-specific biosystem (from WikiPathways)
      Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
    • Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystem (from WikiPathways)
      Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...
    • Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin B12 Metabolism, organism-specific biosystem
      Vitamin B12 Metabolism
    • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
      Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    • Vitamin digestion and absorption, conserved biosystem (from KEGG)
      Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC138242

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    apolipoprotein A-I binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    high-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    high-density lipoprotein particle receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopolysaccharide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    scavenger receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adhesion of symbiont to host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol import ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    detection of lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    high-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle clearance TAS
    Traceable Author Statement
    more info
     
    high-density lipoprotein particle remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intestinal absorption IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cholesterol storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    recognition of apoptotic cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of phagocytosis IC
    Inferred by Curator
    more info
    PubMed 
    regulation of phosphatidylcholine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    reverse cholesterol transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    scavenger receptor class B member 1
    Names
    CD36 and LIMPII analogous 1
    CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
    scavenger receptor class B type III

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028199.1 RefSeqGene

      Range
      5001..91346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001082959.1NP_001076428.1  scavenger receptor class B member 1 isoform 2

      See identical proteins and their annotated locations for NP_001076428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC073593, AC126309, BG770204, CA428516
      Consensus CDS
      CCDS45008.1
      UniProtKB/Swiss-Prot
      Q8WTV0
      Related
      ENSP00000343795.4, OTTHUMP00000239001, ENST00000339570.9, OTTHUMT00000400164
      Conserved Domains (1) summary
      pfam01130
      Location:18446
      CD36; CD36 family
    2. NM_005505.4NP_005496.4  scavenger receptor class B member 1 isoform 1

      See identical proteins and their annotated locations for NP_005496.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC073593, BC080647, BG770204, CA428516
      Consensus CDS
      CCDS9259.1
      UniProtKB/Swiss-Prot
      Q8WTV0
      UniProtKB/TrEMBL
      A0A024RBS4
      Related
      ENSP00000261693.6, OTTHUMP00000239003, ENST00000261693.10, OTTHUMT00000400166
      Conserved Domains (1) summary
      pfam01130
      Location:18446
      CD36; CD36 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      124777628..124863973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      125083775..125169604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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