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    MKI67 marker of proliferation Ki-67 [ Homo sapiens (human) ]

    Gene ID: 4288, updated on 20-May-2018
    Official Symbol
    MKI67provided by HGNC
    Official Full Name
    marker of proliferation Ki-67provided by HGNC
    Primary source
    HGNC:HGNC:7107
    See related
    Ensembl:ENSG00000148773 MIM:176741; Vega:OTTHUMG00000019255
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIA; MIB-; MIB-1; PPP1R105
    Summary
    This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
    Expression
    Biased expression in bone marrow (RPKM 18.5), lymph node (RPKM 8.4) and 12 other tissues See more
    Orthologs
    See MKI67 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (128096659..128126405, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129894923..129924468, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene clarin 3 Neighboring gene protein tyrosine phosphatase, receptor type E Neighboring gene lncRNA antisense to PTPRE protein-coding gene Neighboring gene long intergenic non-protein coding RNA 1163 Neighboring gene VISTA enhancer hs737

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    HIV-1 increases MK167 (Ki67) expression and inversely correlates with PRDM1 (BLIMP1) expression in activated B cells from HIV-1-infected treatment naive individuals PubMed
    HIV-1 infection decreases MKI67 expression in hippocampal sections of brain autopsy tissue PubMed
    HIV-1 upregulates MKI67(Ki-67) in CD4+ and CD8+ T lymphocytes as observed in clinical samples collected from HIV-1 infected patients PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy PubMed
    Pr55(Gag) gag Cellular biotinylated marker of proliferation Ki-67 (MKI67) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag HIV-1 Gag co-localizes with Ki-67 in germinal center of HIV-1 infected patients PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    NOT cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    proliferation marker protein Ki-67
    Names
    antigen Ki67
    antigen identified by monoclonal antibody Ki-67
    proliferation-related Ki-67 antigen
    protein phosphatase 1, regulatory subunit 105

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047061.1 RefSeqGene

      Range
      5160..34705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145966.1NP_001139438.1  proliferation marker protein Ki-67 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL355529, AL390236, BU632619, BU855841, X65551
      Consensus CDS
      CCDS53588.1
      UniProtKB/Swiss-Prot
      P46013
      Related
      ENSP00000357642.3, OTTHUMP00000020740, ENST00000368653.7, OTTHUMT00000051000
      Conserved Domains (4) summary
      COG1716
      Location:11119
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:898
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:643752
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:143185
      PP1_bind; Protein phosphatase 1 binding
    2. NM_002417.4NP_002408.3  proliferation marker protein Ki-67 isoform 1

      See identical proteins and their annotated locations for NP_002408.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL355529, AL390236, BU632619, BU855841, X65550
      Consensus CDS
      CCDS7659.1
      UniProtKB/Swiss-Prot
      P46013
      Related
      ENSP00000357643.3, OTTHUMP00000020739, ENST00000368654.7, OTTHUMT00000050999
      Conserved Domains (4) summary
      COG1716
      Location:11119
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:898
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:10031112
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:503545
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      128096659..128126405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539818.2XP_011538120.1  proliferation marker protein Ki-67 isoform X1

      Conserved Domains (2) summary
      pfam08065
      Location:659768
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:159201
      PP1_bind; Protein phosphatase 1 binding
    2. XM_006717864.3XP_006717927.2  proliferation marker protein Ki-67 isoform X2

      Conserved Domains (1) summary
      pfam08065
      Location:229338
      K167R; K167R (NUC007) repeat
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