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    Pnpla3 patatin-like phospholipase domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 116939, updated on 16-Jul-2017
    Official Symbol
    Pnpla3provided by MGI
    Official Full Name
    patatin-like phospholipase domain containing 3provided by MGI
    Primary source
    MGI:MGI:2151796
    See related
    Ensembl:ENSMUSG00000041653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adpn
    Orthologs
    Location:
    15; 15 E2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (84167784..84189521)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (83998246..84019951)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33432 Neighboring gene predicted gene, 33530 Neighboring gene microRNA 6392 Neighboring gene gamma-secretase subunit PEN-2 pseudogene Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene parvin, beta Neighboring gene predicted gene, 33723

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    diolein transacylation activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysophosphatidic acid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysophosphatidic acid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    lysophosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysophosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    mono-olein transacylation activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    glycerophospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycerophospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid particle organization ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    triglyceride acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    patatin-like phospholipase domain-containing protein 3
    Names
    acylglycerol O-acyltransferase
    adiponutrin
    calcium-independent phospholipase A2-epsilon
    iPLA2-epsilon
    NP_473429.2
    XP_006520408.1
    XP_006520409.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054088.3NP_473429.2  patatin-like phospholipase domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AL626769, BC028792, BY277293
      Consensus CDS
      CCDS37165.1
      UniProtKB/Swiss-Prot
      Q91WW7
      UniProtKB/TrEMBL
      E9QNZ9
      Related
      ENSMUSP00000043826.4, ENSMUST00000045289.4
      Conserved Domains (1) summary
      cd07221
      Location:8259
      Pat_PNPLA3; Patatin-like phospholipase domain containing protein 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      84167784..84189521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520345.3XP_006520408.1  patatin-like phospholipase domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      cd07221
      Location:8259
      Pat_PNPLA3; Patatin-like phospholipase domain containing protein 3
    2. XM_006520346.3XP_006520409.1  patatin-like phospholipase domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      cl11396
      Location:1194
      Patatin_and_cPLA2; Patatins and Phospholipases

    RNA

    1. XR_001781492.1 RNA Sequence

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