Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    GRID1 glutamate ionotropic receptor delta type subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2894, updated on 22-Apr-2017
    Official Symbol
    GRID1provided by HGNC
    Official Full Name
    glutamate ionotropic receptor delta type subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4575
    See related
    Ensembl:ENSG00000182771 MIM:610659; Vega:OTTHUMG00000018650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GluD1
    Summary
    This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
    Orthologs
    Location:
    10q23.1-q23.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (85599555..86366493, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (87359312..88126250, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1520 Neighboring gene uncharacterized LOC105378404 Neighboring gene RNA, U6 small nuclear 325, pseudogene Neighboring gene GRID1 antisense RNA 1 Neighboring gene RNA, 7SK small nuclear pseudogene 238 Neighboring gene RNA, 5S ribosomal pseudogene 322 Neighboring gene microRNA 346 Neighboring gene uncharacterized LOC105378408 Neighboring gene uncharacterized LOC105378407 Neighboring gene RNA, U6 small nuclear 780, pseudogene Neighboring gene WAPL cohesin release factor

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2011-12-21)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2011-12-21)

    ClinGen Genome Curation Page

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
    NHGRI GWA Catalog
    Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
    NHGRI GWA Catalog
    Genetic variants associated with disordered eating.
    NHGRI GWA Catalog
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    NHGRI GWA Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    NHGRI GWA Catalog
    Genome-wide association study of periodontal pathogen colonization.
    NHGRI GWA Catalog
    Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1220

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    extracellular-glutamate-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    glutamate receptor ionotropic, delta-1
    Names
    gluR delta-1 subunit
    glutamate receptor delta-1 subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011875.1 RefSeqGene

      Range
      5001..771939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_017551.2NP_060021.1  glutamate receptor ionotropic, delta-1 precursor

      See identical proteins and their annotated locations for NP_060021.1

      Status: REVIEWED

      Source sequence(s)
      AB033046, AK127168, AK293104, DR001156
      Consensus CDS
      CCDS31236.1
      UniProtKB/Swiss-Prot
      Q9ULK0
      UniProtKB/TrEMBL
      A8KAN9
      Related
      ENSP00000330148.7, OTTHUMP00000020003, ENST00000327946.11, OTTHUMT00000049148
      Conserved Domains (4) summary
      cd06392
      Location:25423
      PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
      cd13730
      Location:436806
      PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
      pfam00060
      Location:564841
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:41400
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      85599555..86366493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539720.2XP_011538022.1  glutamate receptor ionotropic, delta-1 isoform X1

      Related
      ENSP00000433064.1, OTTHUMP00000020002, ENST00000464741.2, OTTHUMT00000049147
      Conserved Domains (4) summary
      cd06392
      Location:25423
      PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
      cd13730
      Location:436806
      PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
      pfam00060
      Location:564841
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:41400
      ANF_receptor; Receptor family ligand binding region

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      87641441..88407991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center