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    Nrp1 neuropilin 1 [ Mus musculus (house mouse) ]

    Gene ID: 18186, updated on 18-Apr-2017
    Official Symbol
    Nrp1provided by MGI
    Official Full Name
    neuropilin 1provided by MGI
    Primary source
    MGI:MGI:106206
    See related
    Ensembl:ENSMUSG00000025810 Vega:OTTMUSG00000061647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrp; NP-1; Npn1; NPN-1; C530029I03
    Orthologs
    Location:
    8 E2; 8 75.78 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (128358283..128505476)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (130882973..131029376)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32590 Neighboring gene uncharacterized LOC105243337 Neighboring gene microRNA 21c Neighboring gene microRNA 1903 Neighboring gene predicted gene, 32643 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 46066 Neighboring gene integrin beta 1 (fibronectin receptor beta)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    semaphorin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    semaphorin receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    semaphorin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    semaphorin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vascular endothelial growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    VEGF-activated neuropilin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    VEGF-activated neuropilin signaling pathway involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis involved in coronary vascular morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis involved in innervation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branchiomotor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration involved in coronary vasculogenesis IC
    Inferred by Curator
    more info
    PubMed 
    cell migration involved in sprouting angiogenesis IC
    Inferred by Curator
    more info
    PubMed 
    cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    commissural neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dichotomous subdivision of terminal units involved in salivary gland branching IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dichotomous subdivision of terminal units involved in salivary gland branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal root ganglion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    facial nerve structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    facioacoustic ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of axon extension involved in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell migration involved in autonomic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    otic placode development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to early endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of axon extension involved in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina vasculature morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    semaphorin-plexin signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    semaphorin-plexin signaling pathway involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic neuron projection guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trigeminal ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trigeminal nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trigeminal nerve structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ventral trunk neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vestibulocochlear nerve structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neurofilament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sorting endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    neuropilin-1
    Names
    A5 protein
    Neuropilin-1 precursor (A5 protein)
    transmembrane receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008737.2NP_032763.2  neuropilin-1 precursor

      See identical proteins and their annotated locations for NP_032763.2

      Status: VALIDATED

      Source sequence(s)
      AC102856, AK164378, BC060129
      Consensus CDS
      CCDS22790.1
      UniProtKB/Swiss-Prot
      P97333
      Related
      ENSMUSP00000026917.8, OTTMUSP00000077982, ENSMUST00000026917.9, OTTMUST00000150414
      Conserved Domains (6) summary
      cd06263
      Location:650803
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:843920
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645804
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      128358283..128505476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530766.3XP_006530829.1  neuropilin-1 isoform X1

      See identical proteins and their annotated locations for XP_006530829.1

      UniProtKB/Swiss-Prot
      P97333
      Conserved Domains (6) summary
      cd06263
      Location:650803
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:843920
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645804
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_006530767.2XP_006530830.1  neuropilin-1 isoform X2

      Conserved Domains (6) summary
      cd06263
      Location:643796
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:836913
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:638797
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. XM_006530768.3XP_006530831.1  neuropilin-1 isoform X3

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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