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    Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20317, updated on 4-Jun-2017
    Official Symbol
    Serpinf1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade F, member 1provided by MGI
    Primary source
    MGI:MGI:108080
    See related
    Ensembl:ENSMUSG00000000753 Vega:OTTMUSG00000006203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pedf; Sdf3; EPC-1; Pedfl; AI195227
    Orthologs
    Location:
    11; 11 B5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (75410029..75422623, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75223531..75236125, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene replication protein A1 Neighboring gene SET and MYND domain containing 4 Neighboring gene predicted gene, 35337 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon hillock ISO
    Inferred from Sequence Orthology
    more info
     
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    pigment epithelium-derived factor
    Names
    SDF-3
    alpha-2 antiplasmin
    caspin
    serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
    serine (or cysteine) proteinase inhibitor, clade F), member 1
    serine (or cysteine) proteinase inhibitor, clade F, member 1
    serpin F1
    stromal cell-derived factor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011340.3NP_035470.3  pigment epithelium-derived factor precursor

      See identical proteins and their annotated locations for NP_035470.3

      Status: VALIDATED

      Source sequence(s)
      AA111321, AF017057, AL591496, D50460
      Consensus CDS
      CCDS25045.1
      UniProtKB/Swiss-Prot
      P97298
      Related
      ENSMUSP00000000769.7, OTTMUSP00000006497, ENSMUST00000000769.13, OTTMUST00000013988
      Conserved Domains (1) summary
      cd02052
      Location:39414
      PEDF; Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      75410029..75422623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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