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    RAD53 serine/threonine/tyrosine protein kinase RAD53 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855950, updated on 8-May-2017
    Gene symbol
    RAD53
    Gene description
    serine/threonine/tyrosine protein kinase RAD53
    Primary source
    SGD:S000006074
    Locus tag
    YPL153C
    Gene type
    protein coding
    RNA name
    serine/threonine/tyrosine protein kinase RAD53
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LSD1; MEC2; SPK1
    See RAD53 in Map Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (261727..264192, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Kip2p Neighboring gene proteinase A Neighboring gene hypothetical protein Neighboring gene peptidylprolyl isomerase RRD2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    deoxyribonucleoside triphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    deoxyribonucleoside triphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleobase-containing compound metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    serine/threonine/tyrosine protein kinase RAD53
    NP_015172.1
    • DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      261727..264192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183967.1NP_015172.1  TPA: serine/threonine/tyrosine protein kinase RAD53 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_015172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22216
      Conserved Domains (3) summary
      cd00060
      Location:63134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14098
      Location:196465
      STKc_Rad53_Cds1; Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1
      pfam00069
      Location:200466
      Pkinase; Protein kinase domain
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