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    STMN1 stathmin 1 [ Homo sapiens (human) ]

    Gene ID: 3925, updated on 8-Nov-2017
    Official Symbol
    STMN1provided by HGNC
    Official Full Name
    stathmin 1provided by HGNC
    Primary source
    HGNC:HGNC:6510
    See related
    Ensembl:ENSG00000117632 MIM:151442; Vega:OTTHUMG00000007389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
    Summary
    This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
    Orthologs
    Location:
    1p36.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (25884186..25906877, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26210670..26233368, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7 Neighboring gene uncharacterized LOC105376885 Neighboring gene microRNA 3917 Neighboring gene RNA, U6 small nuclear 110, pseudogene Neighboring gene platelet activating factor acetylhydrolase 2 Neighboring gene uncharacterized LOC101928216 Neighboring gene exostosin like glycosyltransferase 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies STMN1, a factor involved in microtubule organization, as IN-binding partner PubMed

    Go to the HIV-1, Human Interaction Database

    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
      Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
    • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
      Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.
    • Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem (from Pathway Interaction Database)
      Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem
      Signaling mediated by p38-gamma and p38-delta
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ32206, MGC138869, MGC138870

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of thrombin-activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cellular component movement IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    stathmin
    Names
    leukemia-associated phosphoprotein p18
    metablastin
    oncoprotein 18
    phosphoprotein 19
    phosphoprotein p19
    prosolin
    stathmin 1/oncoprotein 18
    testicular tissue protein Li 189
    transmembrane protein C1orf215

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145454.2NP_001138926.1  stathmin isoform b

      See identical proteins and their annotated locations for NP_001138926.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript, and encodes the longer isoform (b).
      Source sequence(s)
      AK303692, AV714035, BC028398, BG493669
      Consensus CDS
      CCDS44090.1
      UniProtKB/Swiss-Prot
      P16949
      UniProtKB/TrEMBL
      A0A140VJW2
      Related
      ENSP00000410452.2, OTTHUMP00000230726, ENST00000426559.6, OTTHUMT00000385768
      Conserved Domains (1) summary
      pfam00836
      Location:9126
      Stathmin; Stathmin family
    2. NM_005563.3NP_005554.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_005554.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BF686314, BG030679, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      P16949
      Related
      ENSP00000387858.2, OTTHUMP00000008527, ENST00000455785.6, OTTHUMT00000019355
      Conserved Domains (1) summary
      pfam00836
      Location:5140
      Stathmin; Stathmin family
    3. NM_203399.1NP_981944.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_981944.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BG030679, BM563894, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      P16949
      Related
      ENSP00000350531.2, OTTHUMP00000008528, ENST00000357865.6, OTTHUMT00000019357
      Conserved Domains (1) summary
      pfam00836
      Location:5140
      Stathmin; Stathmin family
    4. NM_203401.1NP_981946.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_981946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BG030679, BQ428400, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      P16949
      Related
      ENSP00000382633.1, ENST00000399728.5
      Conserved Domains (1) summary
      pfam00836
      Location:5140
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      25884186..25906877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      26323940..26346632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152497.1: Suppressed sequence

      Description
      NM_152497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Support Center