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    hif-1 HIF (Hypoxia Inducible Factor) homologa [ Caenorhabditis elegans ]

    Gene ID: 180359, updated on 6-Aug-2017
    Gene symbol
    hif-1
    Gene description
    HIF (Hypoxia Inducible Factor) homologa
    Primary source
    WormBase:WBGene00001851
    Locus tag
    CELE_F38A6.3
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    See hif-1 in Map Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (20780502..20784861)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to caloric restriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    HIF (Hypoxia Inducible Factor) homologa
    Hypoxia-inducible factor 1
    NP_001023891.2
    • Confirmed by transcript evidence
    NP_001023892.1
    • Confirmed by transcript evidence
    NP_001023893.1
    • Confirmed by transcript evidence
    NP_001023894.2
    • Confirmed by transcript evidence
    NP_001299994.1
    • Product from WormBase gene class hif;
      Confirmed by transcript evidence
    NP_508008.4
    • Confirmed by transcript evidence

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20780502..20784861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028720.3NP_001023891.2  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023891.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (3) summary
      cd00083
      Location:1066
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:94145
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:236338
      PAS_11; PAS domain
    2. NM_075607.5NP_508008.4  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508008.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (3) summary
      cd00083
      Location:1066
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:94145
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:236338
      PAS_11; PAS domain
    3. NM_001028722.3NP_001023893.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023893.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (4) summary
      smart00091
      Location:89142
      PAS; PAS domain
      cd00083
      Location:1066
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:233312
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:236338
      PAS_11; PAS domain
    4. NM_001313065.1NP_001299994.1  HIF (Hypoxia Inducible Factor) homologa [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXG6
      Conserved Domains (3) summary
      cd00083
      Location:258
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:86137
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:228330
      PAS_11; PAS domain
    5. NM_001028723.2NP_001023894.2  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023894.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (3) summary
      cd00083
      Location:258
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:86137
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:228330
      PAS_11; PAS domain
    6. NM_001028721.2NP_001023892.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGD2
      Conserved Domains (2) summary
      cd00130
      Location:1796
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:20122
      PAS_11; PAS domain
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