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    Fus fused in sarcoma [ Mus musculus (house mouse) ]

    Gene ID: 233908, updated on 28-Mar-2017
    Official Symbol
    Fusprovided by MGI
    Official Full Name
    fused in sarcomaprovided by MGI
    Primary source
    MGI:MGI:1353633
    See related
    Ensembl:ENSMUSG00000030795 Vega:OTTMUSG00000016476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tls; Fus1; D430004D17Rik; D930039C12Rik
    Orthologs
    Location:
    7; 7 F3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (127966788..127982032)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (135110993..135125546)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene protease, serine 8 (prostasin) Neighboring gene protease, serine 36 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif-containing 72

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    polysome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    RNA-binding protein FUS
    Names
    fusion, derived from t(12;16) malignant liposarcoma
    hnRNP P2
    pigpen protein
    protein pigpen
    translocated in liposarcoma

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347649.1NP_001334578.1  RNA-binding protein FUS isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC124461
      Consensus CDS
      CCDS85425.1
      UniProtKB/TrEMBL
      Q8CFQ9
    2. NM_139149.2NP_631888.1  RNA-binding protein FUS isoform 1

      See identical proteins and their annotated locations for NP_631888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK139960, AK145582, BY269119
      Consensus CDS
      CCDS21886.1
      UniProtKB/Swiss-Prot
      P56959
      UniProtKB/TrEMBL
      Q3USY4, Q564D0
      Related
      ENSMUSP00000101858, OTTMUSP00000017730, ENSMUST00000106251, OTTMUST00000039732
      Conserved Domains (3) summary
      COG0724
      Location:257367
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:276361
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:415442
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      127966788..127982032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507760.1XP_006507823.1  RNA-binding protein FUS isoform X2

      Conserved Domains (3) summary
      COG0724
      Location:56162
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:71156
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:210237
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. XM_006507759.1XP_006507822.1  RNA-binding protein FUS isoform X1

      Related
      ENSMUSP00000076801, OTTMUSP00000022652, ENSMUST00000077609, OTTMUST00000049053
      Conserved Domains (3) summary
      COG0724
      Location:256366
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:275360
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:414441
      zf-RanBP; Zn-finger in Ran binding protein and others
    3. XM_017322218.1XP_017177707.1  RNA-binding protein FUS isoform X2

      Conserved Domains (3) summary
      COG0724
      Location:56162
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:71156
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:210237
      zf-RanBP; Zn-finger in Ran binding protein and others
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